Numerical Simulations of Red-Blood Cells in Fluid Flow: A Discrete Multiphysics Study

被引：2

作者：

Rahmat, Amin ^{[1
]}

Kuchel, Philip ^{[2
]}

Barigou, Mostafa ^{[1
]}

Alexiadis, Alessio ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem Engn, Birmingham B15 2TT, W Midlands, England

[2] Univ Sydney, Sch Life & Environm Sci, Sydney, NSW 2006, Australia

来源：

CHEMENGINEERING | 2021年 / 5卷 / 03期

基金：

英国工程与自然科学研究理事会; 澳大利亚研究理事会;

关键词：

discrete multiphysics; the smoothed particle hydrodynamics (SPH) method; fluid-solid interactions (FSI); red-blood cells; numerical modelling; shear flow; SMOOTHED PARTICLE HYDRODYNAMICS; ENZYME-KINETIC EQUATIONS; LATTICE-BOLTZMANN; 2,3-BISPHOSPHOGLYCERATE METABOLISM; COMPUTER-SIMULATION; DEFORMATION; MODEL; MEMBRANE; CAPSULES; DYNAMICS;

D O I：

10.3390/chemengineering5030033

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

In this paper, we present a methodological study of modelling red blood cells (RBCs) in shear-induced flows based on the discrete multiphysics (DMP) approach. The DMP is an alternative approach from traditional multiphysics based on meshless particle-based methods. The proposed technique has been successful in modelling multiphysics and multi-phase problems with large interfacial deformations such as those in biological systems. In this study, we present the proposed method and introduce an accurate geometrical representation of the RBC. The results were validated against available data in the literature. We further illustrate that the proposed method is capable of modelling the rupture of the RBC membrane with minimum computational difficulty.

引用

页数：14

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