Cost-effectiveness of Emollients in the Prevention of Relapse among French Patients with Atopic Dermatitis

被引:6
作者
Cabout, Elise [1 ]
Eymere, Sebastien [1 ]
Launois, Robert [1 ]
Seite, Sophie [2 ]
Delvigne, Veronique [2 ]
Taieb, Charles [3 ,4 ]
Reguiai, Ziad [5 ]
机构
[1] Reseau Evaluat Econ Sante REES, Paris, France
[2] La Roche Posay Dermatol Labs, Levallois Perret, France
[3] European Market Maintenance Assessment, EMMA, Fontenay Sous Bois, France
[4] Hop Necker Enfants Malad, Sante Publ, Paris, France
[5] Polyclin Courlancy Bezannes, Serv Dermatol, Reims, France
关键词
dermatitis; atopic; secondary prevention; cost-benefit analysis; STRENGTHENING MOISTURIZING CREAM; UNCERTAINTY;
D O I
10.2340/00015555-3873
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Atopic dermatitis affects up to 20% of children and quite frequently persists in adulthood. Follow-up, treat ment, and prevention of relapses have an impact on healthcare spending. The aim of this study was to assess the cost-effectiveness of different emollients prescribed for patients with atopic dermatitis in France. A 3-health state Markov model was designed, using French data for resource utilization, price and transition probabilities. The effects of the use of 5 different emollients (A, B, C, D, E) or no emollient were compared. The selected outcome was time (years) without flare-up. The 5-year cost for emollient A is 1,575.64euro, and the effectiveness is 3.89 years without flare-up. Strategy A is the most effective. Compared with treatment E, which was the least expensive emollient, A is more expensive (+481.84euro) and more effective (0.082 years without flare-up). The incremental cost-effectiveness ratio is 5,877.48euro/years without flare-up. In conclusion, treating atopic dermatitis with emollients is a cost-effective strategy.
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页数:7
相关论文
共 37 条
[1]   Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse: A Randomized Double-blind Controlled Multicentre Clinical Trial [J].
Akerstrom, Ulf ;
Reitamo, Sakari ;
Langeland, Tor ;
Berg, Mats ;
Rustad, Lisbeth ;
Korhonen, Laura ;
Loden, Marie ;
Wiren, Karin ;
Grande, Mats ;
Skare, Petra ;
Svensson, Ake .
ACTA DERMATO-VENEREOLOGICA, 2015, 95 (05) :587-592
[2]   Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study [J].
Angelova-Fischer, Irena ;
Rippke, Frank ;
Richter, Daniel ;
Filbry, Alexander ;
Arrowitz, Craig ;
Weber, Teresa ;
Fischer, Tobias W. ;
Zillikens, Detlef .
ACTA DERMATO-VENEREOLOGICA, 2018, 98 (05) :517-523
[3]   Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood:: ISAAC Phases One and Three repeat multicountry cross-sectional surveys [J].
Asher, M. Innes ;
Montefort, Stephen ;
Bjorksten, Bengt ;
Lai, Christopher K. W. ;
Strachan, David P. ;
Weiland, Stephan K. ;
Williams, Hywel .
LANCET, 2006, 368 (9537) :733-743
[4]   Does DEALE-ing stack the deck? [J].
Beck, JR ;
Pauker, SG .
MEDICAL DECISION MAKING, 1999, 19 (04) :503-504
[5]   ACTION OF EMOLLIENT CREAMS AND THEIR ADDITIVES [J].
BLANK, IH .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1957, 164 (04) :412-415
[6]  
Briggs A, 1998, HEALTH ECON, V7, P723, DOI 10.1002/(SICI)1099-1050(199812)7:8<723::AID-HEC392>3.3.CO
[7]  
2-F
[8]   Model Parameter Estimation and Uncertainty: A Report of the ISPOR-SMDM Modeling Good Research Practices Task Force-6 [J].
Briggs, Andrew H. ;
Weinstein, Milton C. ;
Fenwick, Elisabeth A. L. ;
Karnon, Jonathan ;
Sculpher, Mark J. ;
Paltiel, A. David .
VALUE IN HEALTH, 2012, 15 (06) :835-842
[9]   Cost Effectiveness of Emollients in the Prevention of Relapses in Atopic Dermatitis [J].
Cabout, Elise ;
Eymere, Sebastien ;
Launois, Robert ;
Aslanian, Flavia ;
Taieb, Charles ;
Seite, Sophie .
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY, 2020, 13 :987-996
[10]   Exploring uncertainty in cost-effectiveness analysis [J].
Claxton, Karl .
PHARMACOECONOMICS, 2008, 26 (09) :781-798