Sequence space localization in the immune system response to vaccination and disease

被引：67

作者：

Deem, MW ^{[1
]}

Lee, HY

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

[2] Rice Univ, Dept Phys & Astron, Houston, TX 77005 USA

来源：

PHYSICAL REVIEW LETTERS | 2003年 / 91卷 / 06期

关键词：

D O I：

10.1103/PhysRevLett.91.068101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccination creates memory sequences that can increase susceptibility to future exposures to the same disease, is explained as stemming from localization of the immune system response in antibody sequence space. This localization is a result of the roughness in sequence space of the evolved antibody affinity constant for antigen and is observed for diseases with high year-to-year mutation rates, such as influenza.

引用

页码：1 / 068101

页数：4

共 22 条

[1] MUTATION DRIFT AND REPERTOIRE SHIFT IN THE MATURATION OF THE IMMUNE-RESPONSE [J].