Synthesis and docking studies on styryl chromones exhibiting cytotoxicity in human breast cancer cell line

被引：17

作者：

Bhatnagar, Seema ^{[1
]}

Sahi, Shakti ^{[2
]}

Kackar, Puneet ^{[3
,4
]}

Kaushik, Swati ^{[1
]}

Dave, Manan K. ^{[1
]}

Shukla, Akshara ^{[1
]}

Goel, Ashita ^{[1
]}

机构：

[1] Amity Univ Sector 125, Amity Inst Biotechnol, Chem Synth Grp, Noida, India

[2] Gautam Buddha Univ, Sch Biotechnol, Greater Noida 201308, India

[3] Amity Univ Sector 125, Amity Inst Biotechnol, Bioinformat Grp, Noida, India

[4] Italian Inst Technol, Cent Res Labs Genoa Headquarter, Unit Drug Discovery & Dev, I-16163 Genoa, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 16期

关键词：

Estrogen receptor; Styryl chromones; ESTROGEN-RECEPTOR;

D O I：

10.1016/j.bmcl.2010.05.108

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The search for small molecules that preferentially target the functionally important surfaces of estrogen receptor and disrupt the transcriptional activity in the cell has emerged as a promising area towards rationale based drug design. Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ER beta binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4945 / 4950

页数：6

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