Study of a novel hybrid bone cement composed of γ-polyglutamic acid and tricalcium silicate

被引：5

作者：

Chung, Ren-Jei ^{[1
]}

Wang, An-Ni ^{[1
]}

Lin, Kuan-Hung ^{[1
]}

Su, Yu-Chieh ^{[1
]}

机构：

[1] Natl Taipei Univ Technol Taipei Tech, Dept Chem Engn & Biotechnol, Taipei 106, Taiwan

来源：

CERAMICS INTERNATIONAL | 2017年 / 43卷

关键词：

Sol-gel processes; Composites; Silicate; Biomedical applications; IN-VITRO BIOACTIVITY; SOL-GEL GLASSES; C-S-H; MODEL; LAYER;

D O I：

10.1016/j.ceramint.2017.05.310

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Tricalcium silicate (C3S) has been used for biomedical materials. It has good biocompatibility and the ability to self-set, allowing it to serve as a bone cement. After setting, C3S demonstrates some mechanical strength but is easily broken. gamma-Polyglutamic acid (gamma-PGA) is a natural, non-toxic, highly biocompatible and edible polymer. To improve the physical properties of tricalcium silicate cement, in this study, we prepared a gamma-PGA/C3S composite bone cement and tested its properties. The C3S powder was synthesized by the sol-gel method and then mixed with different proportions of gamma-PGA to form the solid agent. Moderate 10 wt% NaH2PO4 solution was subsequently added to form the composite bone cement. After characterizing the material and evaluating its biocompatibility in vitro, the potential of the composite to improve bone cement was investigated.

引用

页码：S814 / S822

页数：9

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