Extranodal natural killer/T-cell lymphoma, nasal type in Taiwan: a relatively higher frequency of T-cell lineage and poor survival for extranasal tumors

被引:43
作者
Jhuang, Jie-Yang [1 ]
Chang, Sheng-Tsung [2 ,3 ]
Weng, Shih-Feng [4 ]
Pan, Shien-Tung [5 ]
Chu, Pei-Yi [6 ,7 ]
Hsieh, Pin-Pen [8 ,9 ]
Wei, Chih-Hsin [10 ]
Chou, Shih-Cheng [11 ]
Koo, Chiew-Loon [12 ]
Chen, Chih-Jung [13 ,14 ,15 ]
Hsu, Jeng-Dong [16 ,17 ]
Chuang, Shih-Sung [2 ,18 ,19 ]
机构
[1] Far Eastern Hosp, Dept Anat Pathol, New Taipei City 22060, Taiwan
[2] Chi Mei Med Ctr, Dept Pathol, Tainan 71004, Taiwan
[3] Natl Tainan Inst Nursing, Dept Nursing, Tainan 71004, Taiwan
[4] Chi Mei Med Ctr, Dept Med Res, Tainan 71004, Taiwan
[5] Miaoli Gen Hosp, Dept Pathol, Miaoli 36054, Taiwan
[6] St Martin De Porres Hosp, Dept Pathol, Chiayi 60069, Taiwan
[7] Fu Jen Catholic Univ, Sch Med, New Taipei City 60069, Taiwan
[8] Kaohsiung Vet Gen Hosp, Dept Pathol & Lab Med, Kaohsiung, Taiwan
[9] Natl Def Med Ctr, Taipei 81362, Taiwan
[10] Natl Taiwan Univ Hosp, Dept Hematooncol, Hsin Chu Branch, Hsinchu 30059, Taiwan
[11] Yuans Gen Hosp, Dept Pathol, Kaohsiung 80249, Taiwan
[12] Tungs Taichung MetroHarbor Hosp, Dept Pathol, Taichung 43304, Taiwan
[13] Changhua Christian Hosp, Dept Surg Pathol, Changhua 50006, Taiwan
[14] Chung Shan Med Univ, Sch Med, Taichung 50006, Taiwan
[15] Jen Teh Jr Coll Med Nursing & Management, Dept Med Technol, Miaoli 50006, Taiwan
[16] Chung Shan Med Univ Hosp, Dept Pathol, Taichung 40201, Taiwan
[17] Chung Shan Med Univ, Sch Med, Taichung 40201, Taiwan
[18] Taipei Med Univ, Taipei 71004, Taiwan
[19] Natl Taiwan Univ, Taipei 71004, Taiwan
关键词
Epstein-Barr virus; Extranodal natural killer/T-cell lymphoma; nasal type; Natural killer/T-cell lymphoma; NK-cell lymphoma; Peripheral T-cell lymphoma Taiwan; TCR gene rearrangement; EPSTEIN-BARR-VIRUS; FEATURES;
D O I
10.1016/j.humpath.2014.11.008
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a predominantly extranodal lymphoma associated with Epstein-Barr virus occurring most frequently in the upper aerodigestive tract. There are limited reports on cellular origin and prognostic factors. We retrospectively investigated 73 cases with a median age of 54 years and a male-female ratio of 2.0:1. The upper aerodigestive tract (nasal group) was the most common site of involvement (51 cases; 70%). The other organs (n = 22; extranasal group) included the skin (12 cases; 16%) and gastrointestinal tract (5; 7%). Of the 70 cases with complete staging, 71% had stage I/II disease. All cases were positive for Epstein-Barr virus by in situ hybridization. Using immunohistochemistry and clonality assay for T-cell receptor gene rearrangement, these tumors were classified into NK (n, = 39; 53%), T (n = 13; 18%), and indeterminate lineage (n = 21; 29%). The only clinicopathological difference among these 3 groups was rare CD5 expression in the NK-cell group. Nasal tumors were more frequently of NK-cell origin, and extranasal tumors were equally of either T- or NK-cell origin. The 5-year overall survival rate was 35.6%. The overall survival time was shorter in the extranasal group, although there was no statistical difference in age, sex, and histologic or immunophenotypic features between the 2 groups. Excluding the cases with indeterminate lineage, 75% of cases were of NK lineage; and 25%, T lineage. Extranasal tumors were more aggressive than their nasal counterparts. A prospective national study is warranted for a better understanding of the clinicopathological and genetic features of this uncommon tumor and the prognostic factors. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:313 / 321
页数:9
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