Placebo-controlled chronic high-frequency stimulation of the subthalamic nucleus preserves dopaminergic nigral neurons in a rat model of progressive parkinsonism

被引：49

作者：

Harnack, Daniel ^{[1
]}

Meissner, Wassilios ^{[2
,3
]}

Jira, Julia A. ^{[4
]}

Winter, Christine ^{[5
]}

Morgenstem, Rudolf ^{[4
]}

Kupsch, Andreas ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Dept Neurol, D-13353 Berlin, Germany

[2] Hop Haut Leveque, CHU Bordeaux, Dept Neurol, Bordeaux, France

[3] CNRS, UMR 5227, Bordeaux, France

[4] Charite Univ Med Berlin, Inst Pharmacol & Toxicol, D-13353 Berlin, Germany

[5] Charite Univ Med Berlin, Dept Psychiat, D-13353 Berlin, Germany

来源：

EXPERIMENTAL NEUROLOGY | 2008年 / 210卷 / 01期

关键词：

D O I：

10.1016/j.expneurol.2007.10.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic high-frequency stimulation (HFS) of the subthalamic nucleus (STN) protects nigral dopaminergic neurons from neurodegeneration in animal models of Parkinson's disease (PD). However, these data are challenged by the lack of control for neuroprotective effects that might be related to tissue damage due to electrode insertion or STN-HFS. Here we report the first placebo-controlled study on continuous STN-HFS in a rat model of PD using an implantable microstimulation system. We found a significant increase of preserved dopaminergic nigral neurons on the lesioned side (expressed as ratio to the non-lesioned side) of approximately 50% in comparison to STN sham-stimulated and STN-naive rats. These data provide evidence for the phenotypic rescue of nigral dopamine neurons by long-term STN-HFS in this animal model of PD. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：257 / 260

页数：4

共 17 条

[1] THE PRIMATE SUBTHALAMIC NUCLEUS .2. NEURONAL-ACTIVITY IN THE MPTP MODEL OF PARKINSONISM [J].

BERGMAN, H ;

WICHMANN, T ;

KARMON, B ;

DELONG, MR .

JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (02) :507-520

[2] Subthalamic nucleus lesions are neuroprotective against terminal 6-OHDA-induced striatal lesions and restore postural balancing reactions [J].

Carvalho, GA ;

Nikkhah, G .

EXPERIMENTAL NEUROLOGY, 2001, 171 (02) :405-417

[3] The effects of electrode material, charge density and stimulation duration on the safety of high-frequency stimulation of the subthalamic nucleus in rats [J].

Harnack, D ;

Winter, C ;

Meissner, W ;

Reum, T ;

Kupsch, A ;

Morgenstern, R .

JOURNAL OF NEUROSCIENCE METHODS, 2004, 138 (1-2) :207-216

[4]

HARNACK D, J NEUROSCI METHODS

[5] Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease [J].

Krack, P ;

Batir, A ;

Van Blercom, N ;

Chabardes, S ;

Fraix, V ;

Ardouin, C ;

Koudsie, A ;

Limousin, PD ;

Benazzouz, A ;

LeBas, JF ;

Benabid, AL ;

Pollak, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (20) :1925-1934

[6] Long-term stimulation of the subthalamic nucleus in hemiparkinsonian rats: neuroprotection of dopaminergic neurons [J].

Maesawa, S ;

Kaneoke, Y ;

Kajita, Y ;

Usui, N ;

Misawa, N ;

Nakayama, A ;

Yoshida, J .

JOURNAL OF NEUROSURGERY, 2004, 100 (04) :679-687

[7] Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations [J].

Meissner, W ;

Leblois, A ;

Hansel, D ;

Bioulac, B ;

Gross, CE ;

Benazzouz, A ;

Boraud, T .

BRAIN, 2005, 128 :2372-2382

[8] Compensatory regulation of striatal neuropeptide gene expression occurs before changes in metabolic activity of basal ganglia nuclei [J].

Meissner, W ;

Dovero, S ;

Bioulac, B ;

Gross, CE ;

Bezard, E .

NEUROBIOLOGY OF DISEASE, 2003, 13 (01) :46-54

[9] Progressive and extensive dopaminergic degeneration induced by convection-enhanced delivery of 6-hydroxydopamine into the rat striatum: a novel rodent model of Parkinson disease [J].

Oiwa, Y ;

Sanchez-Pernaute, R ;

Harvey-White, J ;

Bankiewicz, KS .

JOURNAL OF NEUROSURGERY, 2003, 98 (01) :136-144

[10] Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease [J].

Paul, G ;

Meissner, W ;

Rein, S ;

Harnack, D ;

Winter, C ;

Hosmann, K ;

Morgenstern, R ;

Kupsch, A .

EXPERIMENTAL NEUROLOGY, 2004, 185 (02) :272-280

← 1 2 →