RGD peptide-based non-viral gene delivery vectors targeting integrin αvβ3 for cancer therapy

被引:104
作者
Fu, Shuang [1 ,2 ]
Xu, Xiaodong [2 ]
Ma, Yu [2 ]
Zhang, Shubiao [2 ]
Zhang, Shufen [1 ]
机构
[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian, Peoples R China
[2] Dalian Minzu Univ, Minist Educ, Key Lab Biotechnol & Bioresources Utilizat, Dalian, Peoples R China
基金
中国国家自然科学基金;
关键词
RGD; integrin alpha(v)beta(3); non-viral vector; targeted gene delivery; cancer therapy; ARG-GLY-ASP; POLYMER HYBRID NANOPARTICLES; DNA COMPLEXES; CELL-ADHESION; ENDOTHELIAL-CELLS; BINDING; CHITOSAN; DESIGN; PEG; POLYURETHANES;
D O I
10.1080/1061186X.2018.1455841
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Integrin alpha(v)beta(3) is restrictedly expressed on angiogenic blood vessels and tumour cells. It plays a key role in angiogenesis for tumour growth and metastasis. RGD peptide can specifically recognise the integrin alpha(v)beta(3), which serves as targeted molecular for anti-angiogenesis strategies. Therefore, the targeted delivery of therapeutics by RGD peptide-based non-viral vectors to tumour vasculature and tumour cells is recognised as a promising approach for treating cancer. In this review, we illustrate the interaction between RGD peptide and integrin alpha(v)beta(3) from different perspectives. Meanwhile, four types of RGD peptide-based non-viral gene delivery vectors for cancer therapy, including RGD-based cationic polymers, lipids, peptides and hybrid systems, are summarised. The aim is to particularly highlight the enhanced therapeutic effects and specific targeting ability exhibited by these vectors for cancer gene therapy both in vitro and in vivo.
引用
收藏
页码:1 / 11
页数:11
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