How I treat the older patient with acute myeloid leukemia

被引：165

作者：

Ossenkoppele, Gert ^{[1
]}

Lowenberg, Bob

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Hematol, NL-1007 MB Amsterdam, Netherlands

来源：

BLOOD | 2015年 / 125卷 / 05期

关键词：

STEM-CELL TRANSPLANTATION; MICRORNA-EXPRESSION SIGNATURES; RISK MYELODYSPLASTIC SYNDROME; SOUTHWEST-ONCOLOGY-GROUP; LOW-DOSE CYTARABINE; ELDERLY-PATIENTS; MONOSOMAL KARYOTYPE; INTENSIVE CHEMOTHERAPY; PROGNOSTIC IMPACT; INDUCTION CHEMOTHERAPY;

D O I：

10.1182/blood-2014-08-551499

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myeloid leukemia (AML) in older patients presents a notable therapeutic challenge to the clinical hematologist. The clinical biology of AML among patients is highly heterogeneous. Interpatient variations are relevant for prognosis and treatment choice. Outcome of treatment for patients of advanced age is often compromised by comorbid conditions and an enhanced susceptibility to toxicities from therapy. Here we present selected clinical vignettes that highlight distinct representative situations derived from clinical practice. The vignettes are specifically discussed in light of the perspective of treating older patients with leukemia. We review the clinical significance of various cytogenetic and molecular features of the disease, and we examine the various currently available treatment options as well as the emerging prognostic algorithms that may offer guidance in regard to personalized therapy recommendations. The dilemmas in tailoring treatment selection in this category of patients with AML are the central theme in this discussion.

引用

页码：767 / 774

页数：8

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