Benzothiazole Sulfinate: a Water-Soluble and Slow-Releasing Sulfur Dioxide Donor

被引：56

作者：

Day, Jacob J. ^{[1
]}

Yang, Zhenhua ^{[2
]}

Chen, Wei ^{[1
]}

Pacheco, Armando ^{[1
]}

Xian, Ming ^{[1
,2
]}

机构：

[1] Washington State Univ, Dept Chem, Pullman, WA 99164 USA

[2] Shanxi Univ, Inst Environm Sci, Taiyuan 030006, Shanxi, Peoples R China

来源：

ACS CHEMICAL BIOLOGY | 2016年 / 11卷 / 06期

关键词：

SO2; DONORS; DERIVATIVES; RATS; PATHWAYS; INJURY;

D O I：

10.1021/acschembio.6b00106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sulfur dioxide (SO2) has long -been considered a toxic environmental pollutant and byproduct of industrial processing. Recently become evident that SO2 may also havel:regUlatory functions in mammalian puh-uonary systems. Ho:IV-ever, the study of these effects has proven to be challenging due to the difficulty in administering SO2 in a tellable manner. In this work, we report the diicOvery of a new pH -dependent and watensbluble SO2 donor, benzothiazole sulfinate (BTS): We have found BTS to have slow:I:and sustained SO2 release at physiological pH. Additionally, we have explored its vasorelaxation properties as compated.to the -authentic SO2 gas solutions. The slow. release of BTS should make it.a useful toot for the study of endogenously generated SO2.

引用

页码：1647 / 1651

页数：5

共 28 条

[1]

BROWNBRIDGE P, 1988, SYNTHESIS-STUTTGART, P252

[2]

Chen T., 1994, AM J MED SCI, V333, P249

[3] Sulfur dioxide preconditioning increases antioxidative capacity in rat with myocardial ischemia reperfusion (I/R) injury [J].

Jin, Hong Fang ;

Wang, Yuan ;

Wang, Xin Bao ;

Sun, Yan ;

Tang, Chao Shu ;

Du, Jun Bao .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2013, 32 :56-61

[4] Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats [J].

Jin, Hong-fang ;

Du, Shu-xu ;

Zhao, Xia ;

Wei, Hong-ling ;

Wang, Yan-fei ;

Liang, Yin-fang ;

Tang, Chao-shu ;

Du, Jun-bao .

ACTA PHARMACOLOGICA SINICA, 2008, 29 (10) :1157-1166

[5] The Role of Sulfur Dioxide in the Regulation of Mitochondrion-Related Cardiomyocyte Apoptosis in Rats with Isopropylarterenol-Induced Myocardial Injury [J].

Jin, Hongfang ;

Liu, Angie Dong ;

Holmberg, Lukas ;

Zhao, Manman ;

Chen, Siyao ;

Yang, Jinyan ;

Sun, Yan ;

Chen, Shanshan ;

Tang, Chaoshu ;

Du, Junbao .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (05) :10465-10482

[6] Sulfur dioxide upregulates the aortic nitric oxide pathway in rats [J].

Li, Junling ;

Li, Ruijin ;

Meng, Ziqiang .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 645 (1-3) :143-150

[7] The role of sulfur dioxide as an endogenous gaseous vasoactive factor in synergy with nitric oxide [J].

Li, Junling ;

Meng, Ziqiang .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2009, 20 (03) :166-174

[8] Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats [J].

Li, Wei ;

Tang, Chaoshu ;

Jin, Hongfang ;

Du, Junbao .

ATHEROSCLEROSIS, 2011, 215 (02) :323-330

[9]

Luo L., 2001, BIOCHEM BIOPH RES CO, V415, P61

[10] Benzosulfones as photochemically activated sulfur dioxide (SO2) donors [J].

Malwal, Satish R. ;

Chakrapani, Harinath .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (08) :2399-2406

← 1 2 3 →