A multi-trial diagnostic tool in fin whale (Balaenoptera physalus) skin biopsies of the Pelagos Sanctuary (Mediterranean Sea) and the Gulf of California (Mexico)

被引：31

作者：

Fossi, Maria Cristina ^{[1
]}

Urban, Jorge ^{[2
]}

Casini, Silvia ^{[1
]}

Maltese, Silvia ^{[1
]}

Spinsanti, Giacomo ^{[7
]}

Panti, Cristina ^{[7
]}

Porcelloni, Serena ^{[1
]}

Panigada, Simone ^{[3
]}

Lauriano, Giancarlo ^{[4
]}

Nino-Torres, Carlos ^{[2
]}

Rojas-Bracho, Lorenzo ^{[5
]}

Jimenez, Begona ^{[6
]}

Munoz-Arnanz, Juan ^{[6
]}

Marsili, Letizia ^{[1
]}

机构：

[1] Univ Siena, Dept Environm Sci, I-53100 Siena, Italy

[2] Univ Autonoma Baja California Sur, Dept Biol Marina, La Paz, Mexico

[3] Tethys Res Inst, I-20121 Milan, Italy

[4] ISPRA, Rome, Italy

[5] CICESE, Inst Nacl Ecol, Programa Mammifero Marino, Ensenada, Baja California, Mexico

[6] CSIC, Inst Organ Chem, E-28006 Madrid, Spain

[7] Univ Siena, Dept Evolutionary Biol, I-53100 Siena, Italy

来源：

MARINE ENVIRONMENTAL RESEARCH | 2010年 / 69卷

关键词：

Balaenoptera physalus; Skin biopsy; Mediterranean Sea; Gulf of California; OCs; PAHs; PBDEs; CYP1A1; CYP2B; HSP70; ER alpha; AHR; E2F; 1; CETACEANS; INDUCTION;

D O I：

10.1016/j.marenvres.2009.10.006

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The main objective of this study was to apply a set of sensitive non-lethal biomarkers in skin biopsies of fin whales (Balaenoptera physalus) to evaluate the toxicological status of this mysticete in the Pelagos Sanctuary (Mediterranean Sea) and in the Gulf of California (Sea of Cortez-Mexico) We developed a multi-trial diagnostic tool" (based on field and in vitro studies) combining molecular biomarkers (western blot of CYP1A1 CYP2B) and gene expression (qRT-PCR of HSP70 ER alpha AHR E2F 1) with the analysis of OCs PAHs and PBDEs The study revealed a higher level of toxicological stress in the Mediterranean fin whales (C) 2009 Elsevier Ltd All rights reserved

引用

页码：S17 / S20

页数：4

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