Chemical composition and anti-inflammatory activities of the essential oils from Acacia mearnsii de Wild

被引：17

作者：

Avoseh, Opeyemi N. ^{[1
]}

Oyedeji, Ope-oluwa O. ^{[1
]}

Aremu, Kayode ^{[2
]}

Nkeh-Chungag, Benedicta N. ^{[2
]}

Songca, Sandile P. ^{[3
]}

Oluwafemi, Samuel O. ^{[4
]}

Oyedeji, Adebola O. ^{[3
]}

机构：

[1] Univ Ft Hare, Fac Sci & Agr, Dept Chem, Alice, South Africa

[2] Walter Sisulu Univ, Dept Zool, Fac Sci Engn & Technol, Mthatha, South Africa

[3] Walter Sisulu Univ, Sch Appl & Environm Sci, Dept Chem, Mthatha, South Africa

[4] Cape Peninsula Univ Technol, Dept Chem, ZA-8000 Cape Town, South Africa

来源：

NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 12期

关键词：

inflammation; phytol; egg albumin-induced oedema; essential oils; Acacia mearnsii; cis-verbenol; STEM BARK; EXTRACT;

D O I：

10.1080/14786419.2014.983504

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The volatile oils of the leaves and the stem bark of Acacia mearnsii de Wild obtained by hydro-distillation were analysed by gas chromatography-mass spectrometry. A total of 20, 38, 29 and 38 components accounted for 93.8%, 92.1%, 78.5% and 90.9% of the total oils of the fresh, dry leaves and fresh, dry stem bark, respectively. The major components of the oil were octadecyl alcohol (25.5%) and phytol (10.5%); cis-verbenol (29.5%); phytol (10.1%) and phytol (23.4%) for the fresh leaves, dried leaves, fresh stem, dry stem bark, respectively. Oral administration of essential oils at a dose of 2% showed significant (p<0.05) anti-inflammatory properties in the albumin-induced test model in rats. Oils from the fresh leaves and dry stems inhibited inflammation beyond 4h post treatment. The potent anti-inflammatory activity of essential oils of A. mearnsii hereby confirmed its traditional use in treating various inflammatory diseases.

引用

页码：1184 / 1188

页数：5

共 19 条

[1] Anti-Inflammatory and Analgesic Activities of the Aqueous Extract of Acacia karroo Stem Bark in Experimental Animals [J].

Adedapo, Adeolu A. ;

Sofidiya, Margaret O. ;

Masika, Patrick J. ;

Afolayan, Anthony J. .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2008, 103 (05) :397-400

[2]

Benth C, 1998, FLAVOUR FRAG, V268, P266

[3] Analgesic, anti-inflammatory and anti-platelet activities of the methanolic extract of Acacia modesta leaves [J].

Bukhari I.A. ;

Khan R.A. ;

Gilani A.H. ;

Ahmed S. ;

Saeed S.A. .

Inflammopharmacology, 2010, 18 (4) :187-196

[4] A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation [J].

Burnett, B. P. ;

Jia, Q. ;

Zhao, Y. ;

Levy, R. M. .

JOURNAL OF MEDICINAL FOOD, 2007, 10 (03) :442-451

[5] A Review on Anti-Inflammatory Activity of Phenylpropanoids Found in Essential Oils [J].

da Silveira e Sa, Rita de Cassia ;

Andrade, Luciana Nalone ;

Barreto de Oliveira, Rafael dos Reis ;

de Sousa, Damiao Pergentino .

MOLECULES, 2014, 19 (02) :1459-1480

[6] A Review on Anti-Inflammatory Activity of Monoterpenes [J].

da Silveira e Sa, Rita de Cassia ;

Andrade, Luciana Nalone ;

de Sousa, Damiao Pergentino .

MOLECULES, 2013, 18 (01) :1227-1254

[7]

Hukkeri VI, 2002, INDIAN DRUGS, V39, P664

[8]

Ikarashi N, 2012, EVID BASED COMPLEMEN

[9]

Ikarashi N, 2011, EVID BASED COMPLEMEN

[10]

Joseph J, 2011, J ESSENT OIL RES, V19, P49

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