Motor inhibitory role of dopamine D1 receptors: Implications for ADHD

被引：34
作者：
Heijtz, Rochellys Diaz
Kolb, Bryan
Forssberg, Hans
机构：
[1] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Astrid Lindgren Childrens Hosp, Dept Women & Child Hlth, S-17176 Stockholm, Sweden
[3] Univ Lethbridge, Canadian Ctr Behav Neurosci, Lethbridge, AB T1K 3M4, Canada
来源：
PHYSIOLOGY & BEHAVIOR | 2007年 / 92卷 / 1-2期
基金：
加拿大自然科学与工程研究理事会;
关键词：
dopamine; motor activity; dopamine D1 receptors; prefrontal cortex; ADHD; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; RODENT PREFRONTAL CORTEX; ORBITAL FRONTAL-CORTEX; MESSENGER-RNA; KNOCKOUT MICE; RATS; D-1; CALCYON; BRAIN; SCHIZOPHRENIA;
D O I：
10.1016/j.physbeh.2007.05.024
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Dysregulation of dopamine (DA) neurotransmission in frontal-striatal circuitry has been hypothesized to underlie several neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD). The actions of DA are mediated by five distinct receptor subtypes that belong to the G-protein-coupled receptor super-family and are divided into two major classes, D1-like (D1 and D5) and D2-like (D2, D3, and D4). Accumulating evidence implicates the D1 receptor subtype (D1R) in the regulation of motor and cognitive processes. It is generally assumed that D1R is linked to motor activity in a stimulatory fashion. However, recent findings in rodents suggest a potential role of D1R on motor inhibition, which emerges during late postnatal development. Several lines of evidence indicate that the locus of the inhibitory effects involve subregions of the prefrontal cortex (PFC). These results may be relevant for understanding the neurobiology of ADHD. (C) 2007 Published by Elsevier Inc.
引用
收藏
页码：155 / 160
页数：6
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