Multielectrode Sensing for Extraction of Signal From Noise in Impedance Cytometry

被引：12

作者：

Emaminejad, Sam ^{[1
,2
]}

Talebi, Salmonn ^{[2
,3
]}

Davis, Ronald W. ^{[2
,3
]}

Javanmard, Mehdi ^{[4
]}

机构：

[1] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA

[2] Stanford Sch Med, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA

[3] Stanford Univ, Stanford, CA 94305 USA

[4] Rutgers State Univ, Dept Elect & Comp Engn, New Brunswick, NJ 08904 USA

来源：

IEEE SENSORS JOURNAL | 2015年 / 15卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Coding; cytometry; electrical detection; microfluidics; single-cell detection;

D O I：

10.1109/JSEN.2015.2389224

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We demonstrate a novel multielectrode sensing method for extracting signal from noise in a microfluidic impedance cytometer through introducing redundancy in our measurements and coding the signal. We use a pair of coplanar interdigitated electrodes (IDEs), where we can sense the change in impedance between any two neighboring fingers of the IDE pair. In the context of impedance cytometry, the passage of beads or cells over each two neighboring fingers partially occludes the current measured between the IDE pair. Therefore, as each particle enters and leaves the electrode area, we measure a train of pulses. By applying the equivalent matched filter we can exploit this train of pulses to proportionally increase the signal-to-noise ratio in our measurements.

引用

页码：2715 / 2716

页数：2