In vitro anticancer activity of Sargassum sp. polysaccharides against MCF-7 cell lines

被引：0

作者：

Karthick, V. ^{[1
]}

Akhila, C. ^{[2
]}

Kumar, V. Ganesh ^{[1
]}

Subashini, D. ^{[2
]}

Dhas, T. Stalin ^{[1
]}

Govindaraju, K. ^{[1
]}

Vasanth, K. ^{[3
]}

机构：

[1] Sathyabama Inst Sci & Technol, Ctr Ocean Res, Nanosci Div, Chennai, Tamil Nadu, India

[2] Sathyabama Inst Sci & Technol, Dept Biotechnol, Chennai, Tamil Nadu, India

[3] SRM Inst Sci & Technol, Interdisciplinary Sch Indian Syst Med, Kattankulathur, Tamil Nadu, India

来源：

INDIAN JOURNAL OF GEO-MARINE SCIENCES | 2019年 / 48卷 / 08期

关键词：

Polysaccharides; Spectroscopy; Apoptosis; Sargassum sp; Adenocarcinoma; SULFATED POLYSACCHARIDES; GOLD NANOPARTICLES; BROWN; APOPTOSIS; BIOSYNTHESIS; SWARTZII; TOXICITY; GROWTH;

D O I：

暂无

中图分类号：

P7 [海洋学];

学科分类号：

0707 ;

摘要：

Seaweed polysaccharides are compounds with promising chemopreventive and chemotherapeutic activities. In this study, polysaccharides isolated from Sargassum seaweeds were tested for their efficiency in cancer therapy. Polysaccharides were isolated, purified, and characterized using nuclear magnetic resonance (NMR); and Fourier transform infrared (FT-IR) spectroscopic and matrix-assisted laser desorption ionization mass spectrometric (MALDI-MS). It was found that the polysaccharides from Sargassum sp. branches are sulfated galactose-fucose disaccharides and sulfated galactose monosaccharides attached to the main chain through (1-4) linkages. Further, the polysaccharides were tested for cytotoxicity and anticancer activity against human breast adenocarcinoma cell line (MCF-7) using the Annexin-V/propidium iodide (PI) staining method.

引用

页码：1267 / 1273

页数：7

共 23 条

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