Widespread Divergence Between Incipient Anopheles gambiae Species Revealed by Whole Genome Sequences

被引：208

作者：

Lawniczak, M. K. N. ^{[2
]}

Emrich, S. J. ^{[3
]}

Holloway, A. K. ^{[4
]}

Regier, A. P. ^{[3
]}

Olson, M. ^{[3
]}

White, B. ^{[1
]}

Redmond, S. ^{[2
]}

Fulton, L. ^{[5
]}

Appelbaum, E. ^{[5
]}

Godfrey, J. ^{[5
]}

Farmer, C. ^{[5
]}

Chinwalla, A. ^{[5
]}

Yang, S. -P. ^{[5
]}

Minx, P. ^{[5
]}

Nelson, J. ^{[5
]}

Kyung, K. ^{[5
]}

Walenz, B. P. ^{[6
]}

Garcia-Hernandez, E. ^{[6
]}

Aguiar, M. ^{[6
]}

Viswanathan, L. D. ^{[6
]}

Rogers, Y. -H. ^{[6
]}

Strausberg, R. L. ^{[6
]}

Saski, C. A. ^{[7
]}

Lawson, D. ^{[8
]}

Collins, F. H. ^{[1
]}

Kafatos, F. C. ^{[2
]}

Christophides, G. K. ^{[2
]}

Clifton, S. W. ^{[5
]}

Kirkness, E. F. ^{[6
]}

Besansky, N. J. ^{[1
]}

机构：

[1] Univ Notre Dame, Eck Inst Global Hlth, Dept Biol Sci, Notre Dame, IN 46556 USA

[2] Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London SW7 2AZ, England

[3] Univ Notre Dame, Dept Comp Sci & Engn, Notre Dame, IN 46556 USA

[4] J David Gladstone Inst, San Francisco, CA 94158 USA

[5] Washington Univ, Genome Ctr, St Louis, MO 63108 USA

[6] J Craig Venter Inst, Rockville, MD 20850 USA

[7] Clemson Univ, Clemson Univ Genom Inst, Clemson, SC 29634 USA

[8] European Bioinformat Inst EMBL EBI, Cambridge CB10 1SD, England

来源：

SCIENCE | 2010年 / 330卷 / 6003期

基金：

英国生物技术与生命科学研究理事会;

关键词：

MOLECULAR-FORMS; ECOLOGICAL SPECIATION; GENE FLOW; ISLANDS; SEGREGATION; CULICIDAE; SELECTION; DIPTERA; S.S;

D O I：

10.1126/science.1195755

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Afrotropical mosquito Anopheles gambiae sensu stricto, a major vector of malaria, is currently undergoing speciation into the M and S molecular forms. These forms have diverged in larval ecology and reproductive behavior through unknown genetic mechanisms, despite considerable levels of hybridization. Previous genome-wide scans using gene-based microarrays uncovered divergence between M and S that was largely confined to gene-poor pericentromeric regions, prompting a speciation-with-ongoing-gene-flow model that implicated only about 3% of the genome near centromeres in the speciation process. Here, based on the complete M and S genome sequences, we report widespread and heterogeneous genomic divergence inconsistent with appreciable levels of interform gene flow, suggesting a more advanced speciation process and greater challenges to identify genes critical to initiating that process.

引用

页码：512 / 514

页数：3

共 27 条

[1] Tracking footprints of artificial selection in the dog genome [J].

Akey, Joshua M. ;

Ruhe, Alison L. ;

Akey, Dayna T. ;

Wong, Aaron K. ;

Connelly, Caitlin F. ;

Madeoy, Jennifer ;

Nicholas, Thomas J. ;

Neff, Mark W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (03) :1160-1165

[2] Anopheles gambiae complex along The Gambia river, with particular reference to the molecular forms of An. gambiae s.s [J].

Caputo, Beniamino ;

Nwakanma, Davis ;

Jawara, Musa ;

Adiamoh, Majidah ;

Dia, Ibrahima ;

Konate, Lassana ;

Petrarca, Vincenzo ;

Conway, David J. ;

della Torre, Alessandra .

MALARIA JOURNAL, 2008, 7 (1)

[3] Recombination and Speciation: Loci Near Centromeres Are More Differentiated Than Loci Near Telomeres Between Subspecies of the European Rabbit (Oryctolagus cuniculus) [J].

Carneiro, Miguel ;

Ferrand, Nuno ;

Nachman, Michael W. .

GENETICS, 2009, 181 (02) :593-606

[4]

Costantini Carlo, 2009, BMC Ecology, V9, P16, DOI 10.1186/1472-6785-9-16

[5]

della Torre A, 2001, INSECT MOL BIOL, V10, P9, DOI 10.1046/j.1365-2583.2001.00235.x

[6] On the distribution and genetic differentiation of Anopheles gambiae s.s. molecular forms [J].

della Torre, A ;

Tu, ZJ ;

Petrarca, V .

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2005, 35 (07) :755-769

[7]

Diabaté A, 2006, J MED ENTOMOL, V43, P480, DOI 10.1603/0022-2585(2006)43[480:MSOTMM]2.0.CO

[8]

[9]

Diabaté A, 2007, J MED ENTOMOL, V44, P60, DOI 10.1603/0022-2585(2007)44[60:ETEOPI]2.0.CO

[10]

← 1 2 3 →