Total synthesis and stereochemistry of 13-hydroxy-α-eudesmol

被引：14

作者：

Chen, YG

Xiong, ZM

Zhou, G

Liu, LJ

Li, YL ^{[1
]}

机构：

[1] Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Inst Organ Chem, Lanzhou 730000, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 11期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0957-4166(98)00184-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first total synthesis of both C-11 epimers of 13-hydroxy-alpha-eudesmol 1a and 1b by the use, as a key reaction, of the Sharpless asymmetric dihydroxylation of alkene 7 is presented. The absolute configuration of natural 13-hydroxy-alpha-eudesmol is established through comparison of the H-1 NMR spectrum of natural diol and synthetic diols. In our synthesis another natural product (+)-alpha-selinene 2 has also been accomplished. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1923 / 1928

页数：6

共 11 条

[1] STUDIES ON THE SYNTHESIS OF SESQUITERPENE LACTONES .12. SYNTHESIS OF (+)-COLARTIN, (+)-ARBUSCULIN-A, AND THEIR C-4 EPIMERS AND THEIR BIOLOGICAL-ACTIVITIES [J].