Total synthesis and stereochemistry of 13-hydroxy-α-eudesmol

被引：14
作者：
Chen, YG
Xiong, ZM
Zhou, G
Liu, LJ
Li, YL [1 ]
机构：
[1] Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Lanzhou Univ, Inst Organ Chem, Lanzhou 730000, Peoples R China
来源：
TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 11期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/S0957-4166(98)00184-0
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The first total synthesis of both C-11 epimers of 13-hydroxy-alpha-eudesmol 1a and 1b by the use, as a key reaction, of the Sharpless asymmetric dihydroxylation of alkene 7 is presented. The absolute configuration of natural 13-hydroxy-alpha-eudesmol is established through comparison of the H-1 NMR spectrum of natural diol and synthetic diols. In our synthesis another natural product (+)-alpha-selinene 2 has also been accomplished. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：1923 / 1928
页数：6
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