Hepatitis C virus core antigen in the management of patients treated with new direct-acting antivirals

被引：18

作者：

Alados Arboledas, Juan Carlos ^{[1
]}

Pavon Guerrero, Inmaculada ^{[2
]}

Blanco Rodriguez, Maria Jose ^{[2
]}

Torres Martos, Eva ^{[1
]}

Belen Perez, Ana ^{[3
,4
]}

Cepero Leon, Cristina ^{[2
]}

Sierra Sanchez, Jesus F. ^{[5
]}

Lopez Prieto, Maria Dolores ^{[1
]}

Chueca Porcuna, Natalia ^{[3
,4
]}

Ocete Mochon, Maria Dolores ^{[6
]}

Macias, Juan ^{[7
]}

de la Iglesia Salgado, Alberto ^{[8
]}

Rodriguez Granger, Javier ^{[9
]}

Delgado Fernandez, Marcial ^{[10
]}

Guerrero Lozano, Inmaculada ^{[11
]}

Reigadas Ramirez, Elena ^{[12
]}

Rivero, Antonio ^{[13
]}

Lozano Dominguez, Maria del Carmen ^{[14
]}

Viciana, Isabel ^{[15
]}

Galan Montemayor, Juan Carlos ^{[16
]}

Garcia Garcia, Federico ^{[3
,4
]}

机构：

[1] AGS Norte Cadiz, Microbiol Sect, Cadiz, Spain

[2] AGS Norte Cadiz, Digest Sect, Cadiz, Spain

[3] Hosp Univ San Cecilia, Microbiol Serv, Granada, Spain

[4] Inst Invest Biosanitario Ibs, Granada, Spain

[5] AGS Norte Cadiz, Serv Pharm, Cadiz, Spain

[6] H Gen, Microbiol Serv, Valencia, Spain

[7] H Valme, Infect Dis Unit, Seville, Spain

[8] H Infanta Elena, Microbiol Sect, Huelva, Spain

[9] H Virgen de las Nieves, Microbiol Serv, Granada, Spain

[10] H Carlos Haya, Infect Dis Unit, Malaga, Spain

[11] H Puerta del Mar, Microbiol Serv, Cadiz, Spain

[12] H Gregorio Maranon, Microbiol Serv, Madrid, Spain

[13] H Reina Sofia, Infect Dis Unit, Cordoba, Spain

[14] H Virgen del Rocio, Microbiol Serv, Seville, Spain

[15] H Virgen de la Victoria, Microbiol Serv, Malaga, Spain

[16] H Ramon y Cajal, Microbiol Serv, Madrid, Spain

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2017年 / 89卷 / 01期

关键词：

Hepatitis C; Core antigen; Direct-acting antivirals; Viremia; Monitoring; HCV-RNA; ENZYME-IMMUNOASSAY; INFECTION; ASSAY; DIAGNOSIS; UTILITY;

D O I：

10.1016/j.diagmicrobio.2017.06.006

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We evaluated the utility of Architect core antigen assay Abbott Diagnostics (HCVAg) for monitoring patients with HCV infection and compared to HCV-RNA quantification (Cobas Ampliprep TaqMan-Roche Diagnostics). Samples from 262 patients were studied. Mean baseline HCV RNA and HCVAg levels were similar for responders (6.2 log IU/mL and 3.4 log fmol/L) and non-responders (6.1 log IU/mL and 32 log fmol/L), respectively. Only 10 patients failed to achieve SVR12 and all were detected by both assays. To evaluate HCVAg quantification as a tool for the detection of failure to DAAs, we performed a retrospective study of 132 non-responder patients. Mean HCV RNA and HCVAg levels at the time of detection of therapeutic failure were 5.88 +/- 0.97 log IU/mL and 3.19 +/- 0.79 log fmol/L, respectively. HCVAg (>3 fmol/L) was detected in 130/132 patients (98.5%). HCVAg assay was useful for patient selection and for evaluating virological response to DAAs in the real world. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：29 / 34

页数：6

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