Self-assembled polysaccharide nanogel delivery system for overcoming tumor immune resistance

被引：32

作者：

Muraoka, Daisuke ^{[1
]}

Harada, Naozumi ^{[2
]}

Shiku, Hiroshi ^{[3
]}

Akiyoshi, Kazunari ^{[4
]}

机构：

[1] Aichi Canc Ctr Res Inst, Div Translat Oncoimmunol, Nagoya, Japan

[2] United Immun Co Ltd, Tokyo, Japan

[3] Mie Univ Grad Sch Med, Dept Immuno Gene Therapy, Dept Personalized Canc Immunotherapy, Tsu, Japan

[4] Kyoto Univ Grad Sch Engn, Dept Polymer Chem, Kyoto, Japan

来源：

JOURNAL OF CONTROLLED RELEASE | 2022年 / 347卷

关键词：

Nanogel; Cancer vaccine; Lymph node delivery; Tumor-associated macrophages; Tumor immune resistance; T-CELL EXHAUSTION; DENDRITIC CELLS; LYMPH-NODE; HYDROGEL NANOPARTICLE; LIPID NANOPARTICLES; CATIONIC LIPOSOMES; MACROPHAGES; VACCINE; CANCER; RESPONSES;

D O I：

10.1016/j.jconrel.2022.05.004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In therapeutic cancer vaccines, vaccine antigens must be efficiently delivered to the antigen-presenting cells (dendritic cells and macrophages) located in the lymphoid organs (lymph nodes and spleen) at the appropriate time to induce a potent antitumor immune response. Nanoparticle-based delivery systems in cancer immunotherapy are of great interest in recent year. We have developed a novel cancer vaccine that can use selfassembled polysaccharide nanogel of cholesteryl group-modified pullulan (CHP) as an antigen delivery system for clinical cancer immunotherapy for the first time. Additionally, we recently proposed a novel technology that uses CHP nanogels to regulate the function of tumor-associated macrophages, leading to an improvement in the tumor microenvironment. When combined with other immunotherapies, macrophage function modulation using CHP nanogels demonstrated a potent inhibitory effect against cancers resistant to immune checkpoint inhibition therapies. In this review, we discuss the applications of our unique drug nanodelivery system for CHP nanogels.

引用

页码：175 / 182

页数：8

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