B-alkyl Suzuki-Miyaura cross-coupling reactions with air-stable potassium alkyltrifluoroborates

被引：139

作者：

Molander, GA ^{[1
]}

Yun, CS ^{[1
]}

Ribagorda, M ^{[1
]}

Biolatto, B ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 14期

关键词：

D O I：

10.1021/jo0343331

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed cross-coupling reaction of substituted potassium alkyltrifluoroborates with aryl halides and aryl triflates proceeds readily with moderate to good yields. The potassium alkyltrifluoroborates 1, 2, and 3a-e were easily synthesized and obtained as air-stable crystalline solids that can be stored for long periods of time. All of the cross-couplings proceed under the same reaction conditions using PdCl2(dppf)-CH2Cl2 as catalyst in THF-H2O in the presence of 3 equiv of Cs2CO3 as base.

引用

页码：5534 / 5539

页数：6

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