The ALG-2/AIP-complex, a modulator at the interface between cell proliferation and cell death? A hypothesis

被引：26
|
作者：
Krebs, J
Klemenz, R
机构：
[1] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Inst Biochem, CH-8092 Zurich, Switzerland
[2] Univ Zurich Hosp, Dept Pathol, CH-8091 Zurich, Switzerland
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2000年 / 1498卷 / 2-3期
关键词：
apoptosis; programmed cell death; calcium; ALG-2; AIP; alix; Xp95; confocal microscopy; nuclear envelope breakdown;
D O I：
10.1016/S0167-4889(00)00091-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During the development of an organism cell proliferation, differentiation and cell death are tightly balanced, and are controlled by a number of different regulators. Alterations in this balance are often observed in a variety of human diseases. The role of Ca2+ as one of the key regulators of the cell is discussed with respect to two recently discovered proteins, ALG-2 and AIP, of which the former is a Ca2+-binding protein, and the latter is substrate to various kinases. The two proteins interact with each other in a Ca2+-dependent manner, and the role of the complex ALG-2/AIP as a possible modulator at the interface between cell proliferation and cell death is discussed. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：153 / 161
页数：9
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