Copper-Catalyzed Regio- and Enantioselective Synthesis of Chiral Enol Acetates and β-Substituted Aldehydes

被引：35

作者：

Fananas-Mastral, Martin ^{[1
]}

Feringa, Ben L. ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 38期

关键词：

ASYMMETRIC CONJUGATE ADDITION; LIGANDS; KETONES;

D O I：

10.1021/ja105585y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The in situ transformation of alpha,beta-unsaturated aldehydes into alpha-chloroallylic acetates and subsequent copper-catalyzed regio- and enantioselective (up to 94% ee) allylic alkylation with Grignard reagents provides chiral enol acetates and chiral beta-substituted aldehydes in a one-pot protocol.

引用

页码：13152 / 13153

页数：2

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