N-Hydroxyphthalimide-catalyzed chemoselective intermolecular benzylic C-H amination of unprotected arylalkanols

被引：3
|
作者：
Shibuya, Masatoshi [1 ]
Orihashi, Takayuki [1 ]
Li, Yamei [1 ]
Yamamoto, Yoshihiko [1 ]
机构：
[1] Nagoya Univ, Grad Sch Pharmaceut Sci, Dept Basic Med Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan
来源：
CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 70期
关键词：
FLUORINATED ALCOHOLS; FUNCTIONALIZATION; AMIDATION;
D O I：
10.1039/d1cc03466a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N-Hydroxyphthalimide-catalyzed chemoselective benzylic C(sp(3))-H amination of unprotected arylalkanols using bis(2,2,2-trichloroethyl)azodicarboxylate has been developed. The use of 1,1,1,3,3,3-hexafluoropropan-2-ol as a solvent plays a critical role in chemoselectivity. The conversion of an aminated product to the corresponding free amino alcohol was also demonstrated.
引用
收藏
页码：8742 / 8745
页数：4
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