MMP-9 expression is increased in B lymphocytes during multiple sclerosis exacerbation and is regulated by microRNA-320a

被引：54

作者：

Aung, Latt Latt ^{[1
]}

Mouradian, M. Maral ^{[1
]}

Dhib-Jalbut, Suhayl ^{[1
]}

Balashov, Konstantin E. ^{[1
]}

机构：

[1] Rutgers Robert Wood Johnson Med Sch, Dept Neurol, New Brunswick, NJ 08901 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 278卷

关键词：

Multiple sclerosis; B lymphocytes; MicroRNA; MMP-9; miR-320a; BLOOD-BRAIN-BARRIER; MATRIX METALLOPROTEINASES; CEREBROSPINAL-FLUID; IMMUNE-SYSTEM; CLONAL EXPANSION; INFLAMMATION; RITUXIMAB; THERAPY; CELLS; TRIAL;

D O I：

10.1016/j.jneuroim.2014.11.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cells are necessary to maintain disease activity in relapsing multiple sclerosis (MS) and produce matrix metallopeptidase-9 (MMP-9), which disrupts the blood-brain barrier. MMP-9 protein expression was increased and expression of microRNA-320a (miR-320a), which targets MMP-9 mRNA, was significantly decreased in B lymphocytes of MS patients during a disease relapse compared to remission. Functional significance of these findings was demonstrated by transfecting human B lymphocytes with miR-320a inhibitor, which led to increased MMP-9 expression and secretion. In summary, expression of miR-320a is decreased in B cells of MS patients and may contribute to increased blood-brain barrier permeability and neurological disability. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：185 / 189

页数：5

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