Obesity at adolescence and gastric cancer risk

被引：26
作者：
Song, Minkyo [1 ,2 ,3 ]
Choi, Ji-Yeob [2 ,4 ]
Yang, Jae Jeong [1 ,3 ]
Sung, Hyuna [5 ]
Lee, Yunhee [1 ,2 ]
Lee, Hwi-Won [1 ,2 ]
Kong, Seong-Ho [4 ,6 ]
Lee, Hyuk-Joon [4 ,6 ]
Kim, Hyung-Ho [7 ]
Kim, Sang Gyun [8 ,9 ]
Yang, Han-Kwang [4 ,6 ]
Kang, Daehee [1 ,2 ,4 ]
机构：
[1] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea
[3] Seoul Natl Univ, Med Res Ctr, Inst Environm Med, Seoul, South Korea
[4] Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul, South Korea
[5] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA
[6] Seoul Natl Univ, Coll Med, Dept Surg, Seoul, South Korea
[7] Seoul Natl Univ, Bundang Hosp, Dept Surg, Songnam, South Korea
[8] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea
[9] Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul, South Korea
来源：
CANCER CAUSES & CONTROL | 2015年 / 26卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
Gastric cancer; Epidemiology; Risk; Obesity; Body mass index; Adolescence; BODY-MASS INDEX; FOLLOW-UP; ADENOCARCINOMA; OVERWEIGHT; ESOPHAGUS; HEIGHT; COHORT; ASSOCIATION; CHILDHOOD; STOMACH;
D O I：
10.1007/s10552-014-0506-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
During the last few decades, prevalence of obesity has risen rapidly worldwide, markedly in children and adolescents. Epidemiologic studies have associated obesity to several cancer types, yet little is known for the effect of early life exposure to obesity on cancer risk in later life, especially in gastric cancer. Thus, the present study aimed to investigate the association of body mass index (BMI) of adolescence and the risk of gastric cancer. A multicenter case-control study was conducted between 2010 and 2014 in Korea with 1,492 incident gastric cancer cases and 1,492 controls matched by age and sex. The BMI at age 18 was calculated by using weight and height from questionnaire. The association with the risk of gastric cancer was evaluated using odds ratios by logistic regression model adjusted for potential confounding factors. Compared with BMI 21.75 kg/m(2), higher BMI at age 18 was associated with higher risk of gastric cancer showing a nonlinear, threshold effect. Statistically significant odds ratio was observed in men with BMI higher than 25.3 kg/m(2) (OR 1.13, 95 % CI 1.01-1.27) and in women with BMI 25.3 kg/m(2) and above (OR 1.25, 95 % CI 1.01-1.55). Similar to some other cancer types, overweight or obese in adolescence was found to be associated with the increased risk of gastric cancer. The results imply for stratified approach of tactics in prevention of gastric cancer in different population.
引用
收藏
页码：247 / 256
页数：10
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