Metabolomics in pesticide research and development: review and future perspectives

被引：89

作者：

Aliferis, Konstantinos A. ^{[1
]}

Chrysayi-Tokousbalides, Maria ^{[2
]}

机构：

[1] McGill Univ, Dept Plant Sci, Ste Anne De Bellevue, PQ H9X 3V9, Canada

[2] Agr Univ Athens, Pesticide Sci Lab, Athens 11855, Greece

来源：

METABOLOMICS | 2011年 / 7卷 / 01期

关键词：

Bioactive compounds; Crop protection; Natural products; Pesticides; NUCLEAR-MAGNETIC-RESONANCE; HERBICIDE-RESISTANT CROPS; HPLC-NMR-MS; MASS-SPECTROMETRY; CAPILLARY-ELECTROPHORESIS; ENVIRONMENTAL METABOLOMICS; H-1-NMR SPECTROSCOPY; FUNCTIONAL GENOMICS; NATURAL-PRODUCTS; MOLECULAR-MECHANISMS;

D O I：

10.1007/s11306-010-0231-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The emerge of metabolomics within functional genomics has provided a new dimension in the study of biological systems. In regards to the study of agroecosystems, metabolomics enables monitoring of metabolic changes in association with biotic or abiotic agents such as agrochemicals. Focusing on crop protection chemicals, a great effort has been given towards the development of crop protection agents safer for consumers and the environment and more efficient than the existing ones. Within this framework, metabolomics has so far been a valuable tool for high-throughput screening of bioactive substances in order to discover those with high selectivity, unique modes-of-action, and acceptable eco-toxicological/toxicological profiles. Here, applications of metabolomics in the investigation of the modes-of-action and ecotoxicological-toxicological risk assessment of bioactive compounds, mining of biological systems for the discovery of bioactive metabolites, and the risk assessment of genetic modified crops are discussed.

引用

页码：35 / 53

页数：19

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