Non-coding RNAs as regulators of embryogenesis

被引：487

作者：

Pauli, Andrea ^{[1
,2
]}

Rinn, John L. ^{[2
,3
]}

Schier, Alexander F. ^{[1
,2
,3
,4
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[3] Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[4] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA

来源：

NATURE REVIEWS GENETICS | 2011年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

DROSOPHILA DOSAGE COMPENSATION; X-CHROMOSOME INACTIVATION; TO-ZYGOTIC TRANSITION; MIR-200; FAMILY; STEM-CELLS; MESENCHYMAL TRANSITION; MICRORNA BIOGENESIS; GENE-EXPRESSION; REPRESSORS ZEB1; MESSENGER-RNAS;

D O I：

10.1038/nrg2904

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Non-coding RNAs (ncRNAs) are emerging as key regulators of embryogenesis. They control embryonic gene expression by several means, ranging from microRNA-induced degradation of mRNAs to long ncRNA-mediated modification of chromatin. Many aspects of embryogenesis seem to be controlled by ncRNAs, including the maternal-zygotic transition, the maintenance of pluripotency, the patterning of the body axes, the specification and differentiation of cell types and the morphogenesis of organs. Drawing from several animal model systems, we describe two emerging themes for ncRNA function: promoting developmental transitions and maintaining developmental states. These examples also highlight the roles of ncRNAs in ensuring a robust commitment to one of two possible cell fates.

引用

页码：136 / 149

页数：14

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