From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts

被引：10

作者：

Gliozzi, Micaela ^{[1
]}

Macri, Roberta ^{[1
]}

Coppoletta, Anna Rita ^{[1
]}

Musolino, Vincenzo ^{[2
]}

Carresi, Cristina ^{[3
]}

Scicchitano, Miriam ^{[1
]}

Bosco, Francesca ^{[1
]}

Guarnieri, Lorenza ^{[1
]}

Cardamone, Antonio ^{[1
]}

Ruga, Stefano ^{[1
]}

Scarano, Federica ^{[1
]}

Nucera, Saverio ^{[1
]}

Mollace, Rocco ^{[1
]}

Bava, Irene ^{[1
]}

Caminiti, Rosamaria ^{[1
]}

Serra, Maria ^{[1
]}

Maiuolo, Jessica ^{[2
]}

Palma, Ernesto ^{[3
]}

Mollace, Vincenzo ^{[1
,4
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Pharmacol Lab, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy

[2] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Pharmaceut Biol Lab, I-88100 Catanzaro, Italy

[3] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Vet Pharmacol Lab, I-88100 Catanzaro, Italy

[4] Renato Dulbecco Inst, I-88046 Catanzaro, Italy

来源：

NUTRIENTS | 2022年 / 14卷 / 18期

关键词：

diabetes; insulin resistance; lipid accumulation; inflammation; reactive oxygen species (ROS); SGLT2; inhibitors; nutraceutical supplementation; cardiovascular risk; INSULIN-RESISTANCE; ANTIOXIDANT STATUS; BERBERIS-VULGARIS; OXIDATIVE STRESS; M2; MACROPHAGES; PPAR-GAMMA; RATS; INFLAMMATION; MELLITUS; METAANALYSIS;

D O I：

10.3390/nu14183737

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Diabetes is a complex chronic disease, and among the affected patients, cardiovascular disease (CVD)is the most common cause of death. Consequently, the evidence for the cardiovascular benefit of glycaemic control may reduce long-term CVD rates. Over the years, multiple pharmacological approaches aimed at controlling blood glucose levels were unable to significantly reduce diabetes-related cardiovascular events. In this view, a therapeutic strategy combining SGLT2 inhibitors and plant extracts might represent a promising solution. Indeed, countering the main cardiometabolic risk factor using plant extracts could potentiate the cardioprotective action of SGLT2 inhibitors. This review highlights the main molecular mechanisms underlying these beneficial effects that could contribute to the better management of diabetic patients.

引用

页数：16

共 110 条

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