Synthesis and antimicrobial evaluation of some new 2-(2-(p-chlorophenyl) benzimidazol-1-yl methyl)-5-substituted amino-[1,3,4]-thiadiazoles

被引：0

作者：

Kilcigil, GA ^{[1
]}

Kus, C

Altanlar, N

Özbey, S

机构：

[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Ankara Univ, Fac Pharm, Dept Microbiol, TR-06100 Ankara, Turkey

[3] Hacettepe Univ, Dept Engn Phys, TR-06532 Ankara, Turkey

来源：

TURKISH JOURNAL OF CHEMISTRY | 2005年 / 29卷 / 02期

关键词：

benzimidazoles; thiadiazoles; antimicrobial activity; X-ray;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some 2-(2-(p-chlorophenyl)benzimidazol-1-ylmethyl)-5-substituted amino-[1,3,4]-thiadiazoles were synthesized and their in vitro antimicrobial activities were tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans and Candida krusei. Compounds 1b and 12b which possess remarkable activity against C. albicans and marginal activity against C. krusei were found to be the most active compounds in this series. Single crystal X-ray diffraction analysis was performed for compound 8b.

引用

页码：153 / 162

页数：10

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