Mutator phenotypes due to DNA replication infidelity

被引：72

作者：

Arana, Mercedes E.

Kunkel, Thomas A. ^{[1
]}

机构：

[1] NIEHS, Mol Genet Lab, Res Triangle Pk, NC 27709 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2010年 / 20卷 / 05期

关键词：

Fidelity; DNA polymerase; DNA replication; Mutator phenotypes; Microsatellite instability; XERODERMA-PIGMENTOSUM VARIANT; POLYMERASE-ETA; MISMATCH REPAIR; TRANSLESION SYNTHESIS; SOMATIC HYPERMUTATION; MICROSATELLITE INSTABILITY; SACCHAROMYCES-CEREVISIAE; AFFINITY MATURATION; COLORECTAL-CANCER; ESCHERICHIA-COLI;

D O I：

10.1016/j.semcancer.2010.10.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This article considers the fidelity of DNA replication performed by eukaryotic DNA polymerases involved in replicating the nuclear genome. DNA replication fidelity can vary widely depending on the DNA polymerase, the composition of the error, the flanking sequence, the presence of DNA damage and the ability to correct errors. As a consequence, defects in processes that determine DNA replication fidelity can confer strong mutator phenotypes whose specificity can help determine the molecular nature of the defect. Published by Elsevier Ltd.

引用

页码：304 / 311

页数：8

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