The Role of Tumor Microenvironment in Cancer Immunotherapy

被引：0

作者：

Chen Xue-Man ^{[1
,2
]}

Song Er-Wei ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Breast Tumor Ctr, Sun Yat Sen Mem Hosp, Guangzhou 510120, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Sun Yat Sen Mem Hosp, Guangzhou 510120, Guangdong, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2017年 / 44卷 / 08期

基金：

中国国家自然科学基金;

关键词：

tumor microenvironment; immune tolerance; cancer immunotherapy; REGULATORY T-CELLS; ANGIOGENESIS; MACROPHAGES; METASTASIS; IDENTIFICATION; RECRUITMENT; PROGRESSION; CARCINOMAS; INDUCTION; GROWTH;

D O I：

10.16476/j.pibb.2017.0260

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer pathogenesis in human is comprised by a series of complicated biological processes, whereby the rivalry between foreign tumor and inherent immunity determines the success or failure of this defense battle. As the "seed and soil" hypothesis implicated, tumor initiation and progression are not only driven by (epi) genetic abnormalities, but also influenced by surrounding tumor microenvironment, which adds another layer of understanding to cancer biology. More importantly, growing microenvironment-related studies provide the theoretical reasons for developing more effective cancer immunotherapy in clinical practice. In this review, we will present an overview of tumor microenvironmental components involving immune tolerance, as well as selective research advances in cancer immunotherapy.

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收藏

页码：641 / 648

页数：8

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