Chiral phosphine oxides in present-day organocatalysis

被引：135

作者：

Benaglia, Maurizio ^{[1
]}

Rossi, Sergio ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 17期

关键词：

CATALYTIC ENANTIOSELECTIVE CYANOSILYLATION; LEWIS-BASE ACTIVATION; ASYMMETRIC ALLYLATION; ALDOL REACTION; ALDEHYDES; KETONES; BINAPO; ACIDS;

D O I：

10.1039/c004681g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The design and synthesis of new chiral Lewis bases is a field of extraordinary activity; in this context, while N-oxides derived from both N-heterocyclic systems and aliphatic amines have found widespread applications in organocatalysis, quite surprisingly phosphine oxides have been used less frequently. This contribution will highlight the relatively few examples of stereoselective transformations organocatalyzed by chiral phosphine oxides, discussing the different proposed reaction mechanisms and identifying topics for future investigation in what can be most certainly defined as an "Emerging Area".

引用

页码：3824 / 3830

页数：7

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