Elevated serum anti-mullerian hormone in adolescent and young adult Chinese patients with polycystic ovary syndrome

被引：37

作者：

Li, Lin ^{[1
]}

Chen, Xiaoli ^{[1
]}

Mo, Yaqin ^{[1
]}

Chen, Yaxiao ^{[1
]}

Wenig, Meiying ^{[1
]}

Yang, Dongzi ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Obstet & Gynecol, Guangzhou 510120, Guangdong, Peoples R China

来源：

WIENER KLINISCHE WOCHENSCHRIFT | 2010年 / 122卷 / 17-18期

关键词：

Polycistic ovary syndrome (PCOS); Anti-mullerian hormone (AMH); diagnostic value; adolescence; Chinese; INHIBITING SUBSTANCE; EXPRESSION; WOMEN; GENE;

D O I：

10.1007/s00508-010-1426-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purposes: To explore the serum anti-mullerian hormone (AMH) level in adolescent and young adult Chinese patients with polycystic ovary syndrome (PCOS), and to evaluate its diagnostic value for PCOS. Study design: Serum AMH was measured in a cohort of 47 adolescent and young adult Chinese patients with PCOS and 40 age-matched controls. Its diagnostic potential was evaluated by Receiver Operating Characteristic (ROC) curves. Results: The serum AMH level was higher in PCOS patients than in controls (9.85 +/- 4.93 ng/mL vs. 7.13 +/- 3.02 ng/mL, P = 0.002), and positively related to the mean ovarian volume in PCOS patients (r = 0.319, P = 0.029). The area under the ROC curve for AMH reached a value of 0.664 (0.551-0.778, 95% confidence interval). The best compromise between specificity (70%) and sensitivity (61.7%) was obtained with a cut-off value of 8 ng/mL. Conclusions: Serum AMH levels are elevated in adolescent and young adult Chinese patients of PCOS. Serum AMH measurement offers a relatively poor diagnostic potency with a sensitivity of 61.7% and a specificity of 70% at 8 ng/mL.

引用

页码：519 / 524

页数：6

共 26 条

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