Acetate metabolism and aging: An emerging connection

被引：56

作者：

Shimazu, Tadahiro ^{[1
,2
]}

Hirschey, Matthew D. ^{[1
,2
]}

Huang, Jing-Yi ^{[1
,2
]}

Ho, Linh T. Y. ^{[1
,2
]}

Verdin, Eric ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2010年 / 131卷 / 7-8期

关键词：

Sirtuins; Mitochondria; AceCS2; Acetate; Aging; ACETYL-COA SYNTHETASE; COENZYME-A SYNTHETASE; ELEMENT-BINDING PROTEINS; FATTY-ACID OXIDATION; SACCHAROMYCES-CEREVISIAE; CALORIE RESTRICTION; BACILLUS-SUBTILIS; HISTONE ACETYLATION; SALMONELLA-ENTERICA; LYSINE ACETYLATION;

D O I：

10.1016/j.mad.2010.05.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sirtuins are NAD(+)-dependent protein deacetylases that regulate gene silencing, energy metabolism and aging from bacteria to mammals. SIRT3, a mammalian mitochondrial sirtuin, deacetylates acetyl-CoA synthetase (AceCS2) in the mitochondria. AceCS2 is conserved from bacteria to humans, catalyzes the conversion of acetate to acetyl-CoA and enables peripheral tissues to utilize acetate during fasting conditions. Here, we review the regulation of acetate metabolism by sirtuins, the remarkable conservation of this metabolic regulatory pathway and its emerging role in the regulation of aging and longevity. (c) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：511 / 516

页数：6

共 59 条

[1] A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis [J].

Ahn, Bong-Hyun ;

Kim, Hyun-Seok ;

Song, Shiwei ;

Lee, In Hye ;

Liu, Jie ;

Vassilopoulos, Athanassios ;

Deng, Chu-Xia ;

Finkel, Toren .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (38) :14447-14452

[2] ORIGINS OF BLOOD ACETATE IN RAT [J].

BUCKLEY, BM ;

WILLIAMSON, DH .

BIOCHEMICAL JOURNAL, 1977, 166 (03) :539-545

[3] ADAPTATION TO ALCOHOLIC FERMENTATION IN DROSOPHILA - A PARALLEL SELECTION IMPOSED BY ENVIRONMENTAL ETHANOL AND ACETIC-ACID [J].

CHAKIR, M ;

PERIDY, O ;

CAPY, P ;

PLA, E ;

DAVID, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3621-3625

[4] CLONING AND DISRUPTION OF A GENE REQUIRED FOR GROWTH ON ACETATE BUT NOT ON ETHANOL - THE ACETYL-COENZYME-A SYNTHETASE GENE OF SACCHAROMYCES-CEREVISIAE [J].

DEVIRGILIO, C ;

BURCKERT, N ;

BARTH, G ;

NEUHAUS, JM ;

BOLLER, T ;

WIEMKEN, A .

YEAST, 1992, 8 (12) :1043-1051

[5] Calorie restriction and the nutrient sensing signaling pathways [J].

Dilova, I. ;

Easlon, E. ;

Lin, S. -J. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2007, 64 (06) :752-767

[6] Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae [J].

Falcon, Alaric A. ;

Chen, Shaoping ;

Wood, Michael S. ;

Aris, John P. .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2010, 333 (1-2) :99-108

[7] Recent progress in the biology and physiology of sirtuins [J].

Finkel, Toren ;

Deng, Chu-Xia ;

Mostoslavsky, Raul .

NATURE, 2009, 460 (7255) :587-591

[8] Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins [J].

Frye, RA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 273 (02) :793-798

[9] Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity [J].

Frye, RA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 260 (01) :273-279

[10] Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate [J].

Fujino, T ;

Kondo, J ;

Ishikawa, M ;

Morikawa, K ;

Yamamoto, TT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (14) :11420-11426

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