Concepts in solid tumor evolution

被引：42

作者：

Sidow, Arend ^{[1
]}

Spies, Noah

机构：

[1] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

来源：

TRENDS IN GENETICS | 2015年 / 31卷 / 04期

关键词：

CLONAL EVOLUTION; INTRATUMOR HETEROGENEITY; CANCER; MUTATIONS; LANDSCAPE; REVEALS; TISSUES;

D O I：

10.1016/j.tig.2015.02.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Evolutionary mechanisms in cancer progression give tumors their individuality. Cancer evolution is different from organismal evolution, however, and we discuss where concepts from evolutionary genetics are useful or limited in facilitating an understanding of cancer. Based on these concepts we construct and apply the simplest plausible model of tumor growth and progression. Simulations using this simple model illustrate the importance of stochastic events early in tumorigenesis, highlight the dominance of exponential growth over linear growth and differentiation, and explain the clonal substructure of tumors.

引用

页码：208 / 214

页数：7

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