Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses

被引：162
作者：
Miwa, Julie M. [1 ]
Freedman, Robert [2 ]
Lester, Henry A. [1 ]
机构：
[1] CALTECH, Div Biol, Pasadena, CA 91125 USA
[2] Univ Colorado Denver, Dept Pharmacol & Psychiat, Aurora, CO 80045 USA
来源：
NEURON | 2011年 / 70卷 / 01期
基金：
美国国家卫生研究院;
关键词：
FRONTAL-LOBE EPILEPSY; MIDBRAIN DOPAMINE NEURONS; MESSENGER-RNA EXPRESSION; RAT HIPPOCAMPAL SLICES; LONG-TERM POTENTIATION; IN-VIVO; CHOLINERGIC-RECEPTOR; SYNAPTIC PLASTICITY; ALPHA-BUNGAROTOXIN; PARKINSONS-DISEASE;
D O I：
10.1016/j.neuron.2011.03.014
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cholinergic neurons and nicotinic acetylcholine receptors (nAChRs) in the brain participate in diverse functions: reward, learning and memory, mood, sensory processing, pain, and neuroprotection. Nicotinic systems also have well-known roles in drug abuse. Here, we review recent insights into nicotinic function, linking exogenous and endogenous manipulations of nAChRs to alterations in synapses, circuits, and behavior. We also discuss how these contemporary advances can motivate attempts to exploit nicotinic systems therapeutically in Parkinson's disease, cognitive decline, epilepsy, and schizophrenia.
引用
收藏
页码：20 / 33
页数：14
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