Chemical profiling, in vitro biological activities and Pearson correlation between phenolic contents and antioxidant activities of Caragana brachyantha Rech.f

被引：17
作者：
Ali, Liaquat [1 ]
Khan, Saima [1 ]
Nazir, Mamona [2 ]
Raiz, Naheed [1 ]
Naz, Saima [1 ]
Zengin, Gokhan [3 ]
Mukhtar, Mahreen [1 ]
Parveen, Shehla [2 ]
Shazmeen, Natasha [1 ]
Saleem, Muhammad [1 ]
Tareen, Rasool Baksh [4 ]
机构：
[1] Islamia Univ Bahawalpur, Dept Chem, Baghdad Ul Jadeed Campus, Bahawalpur 63100, Pakistan
[2] Govt Sadiq Women Coll Univ, Dept Chem, Bahawalpur 63100, Pakistan
[3] Selcuk Univ, Fac Sci, Dept Biol, Konya, Turkey
[4] Baluchistan Univ Quetta, Dept Bot, Quetta, Pakistan
来源：
SOUTH AFRICAN JOURNAL OF BOTANY | 2021年 / 140卷
关键词：
Caragana brachyantha; UHPLC-MS analysis; Phenolics; Flavonoids; Antioxidant; Pearson correlation; alpha-Glucosidase; Tyrosinase; BIOACTIVE COMPOUNDS; CONSTITUENTS; EXTRACTS; L; PHYTOCHEMICALS; INHIBITION;
D O I：
10.1016/j.sajb.2021.04.009
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Caragana is one of the most important genera of the plant family Fabaceae, and is famous for conventional folklore medicines applications. Therefore, the present investigation was designed to explore therapeutical potentials of various extracts of Caragana brachyantha Rech.f (Hexane, Ethyl acetate, n-Butanol, Methanol, aqueous) through in vitro biological screening. The UHPLC-MS analysis of the extracts disclosed phytochemical composition and total bioactive contents. Ethyl acetate extract (CBEA) offered the highest phenolic (48.49 +/- 1.23 mgGAE/g extract) and flavonoid (16.48 +/- 0.26 mgRE/g extract) contents and also exhibited significant antioxidant activities. The observed antioxidant potential was further supported by Pearson correlation studies, which depicted a positive relationship between total phenolic contents (TPC) and total flavonoid contents (TFC). Methanolic extract (CBM) exhibited the highest anti-alpha-glucosidase activity (2.02 +/- 0.02 mmolACAE/g extract) while CBEA was found more active (96.02 +/- 3.24 mgKAE/g extract) in tyrosinase inhibition assay. This investigation suggests potential uses of Caragana brachyantha in nutraceutical and pharmaceutical products and thus offers a great industrial application. (C) 2021 SAAB. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：189 / 193
页数：5
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