Boron trifluoride etherate on silica-A modified Lewis acid reagent (VII). Antitumor activity of Cannabigerol against human oral epitheloid carcinoma cells

被引：32

作者：

Baek, SH ^{[1
]}

Kim, YO

Kwag, JS

Choi, KE

Jung, WY

Han, DS

机构：

[1] Wonkwang Univ, Dept Chem, Iksan 570749, South Korea

[2] Mokpo Jr Coll, Dept Dent Hyg, Mokpo 530730, South Korea

[3] Wonkwang Univ, Dept Oral Anat, Iksan 570749, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1998年 / 21卷 / 03期

关键词：

Cannabinoid; 5-fluorouracil; Cannabigerol; antitumor activity; human oral epitheloid carcinoma cell; MTTassay; SRB assay;

D O I：

10.1007/BF02975301

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Geraniol (1), olivetol (2), cannabinoids (3 and 4) and 5-fluorouracil (5) were tested for their growth inhibitory effects against human oral epitheloid carcinoma cell lines (KB) and NIH 3T3 fibroblasts using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.

引用

页码：353 / 356

页数：4

共 17 条

[1]

BAEK SH, 1995, B KOR CHEM SOC, V16, P293

[2] Synthesis and antitumor activity of cannabigerol [J].