Radiation protraction schedules for low-grade gliomas: a comparison between different mathematical models

被引：9

作者：

Budia, I. ^{[1
,2
]}

Alvarez-Arenas, A. ^{[1
,2
]}

Woolley, T. E. ^{[3
]}

Calvo, G. F. ^{[1
,2
]}

Belmonte-Beitia, J. ^{[1
,2
]}

机构：

[1] Univ Castilla La Mancha, Dept Math, E-13071 Ciudad Real, Spain

[2] Univ Castilla La Mancha, MoLAB Math Oncol Lab, E-13071 Ciudad Real, Spain

[3] Cardiff Univ, Sch Math, Senghennydd Rd, Cardiff CF24 4AG, S Glam, Wales

来源：

JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2019年 / 16卷 / 161期

关键词：

mathematical models; optimization problem; low-grade glioma; radiotherapy; TUMOR-GROWTH; NORMAL TISSUE; BRAIN-TUMORS; GLIOBLASTOMA; RADIOTHERAPY; CHEMOTHERAPY; TEMOZOLOMIDE; ORGANIZATION; MANAGEMENT; RESECTION;

D O I：

10.1098/rsif.2019.0665

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We optimize radiotherapy (RT) administration strategies for treating low-grade gliomas. Specifically, we consider different tumour growth laws, both with and without spatial effects. In each scenario, we find the optimal treatment in the sense of maximizing the overall survival time of a virtual low-grade glioma patient, whose tumour progresses according to the examined growth laws. We discover that an extreme protraction therapeutic strategy, which amounts to substantially extending the time interval between RT sessions, may lead to better tumour control. The clinical implications of our results are also presented.

引用

页数：13

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