Obstacle-free planar hybrid micromixer with low pressure drop

被引:29
作者
Bazaz, Sajad Razavi [1 ,2 ]
Amiri, Hoseyn A. [3 ,4 ,5 ]
Vasilescu, Steven [1 ]
Mehrizi, Ali Abouei [6 ]
Jin, Dayong [2 ,7 ]
Miansari, Morteza [3 ,5 ]
Warkiani, Majid Ebrahimi [1 ,2 ,7 ,8 ]
机构
[1] Univ Technol Sydney, Sch Biomed Engn, Sydney, NSW 2007, Australia
[2] Univ Technol Sydney, Fac Sci, Inst Biomed Mat & Devices IBMD, Sydney, NSW 2007, Australia
[3] Babol Noshirvani Univ Technol, Dept Mech Engn, Micro Nanosyst & Appl Biophys Lab, Babol Sar 484, Iran
[4] Iran Univ Sci & Technol, Sch Mech Engn, Sensors & Integrated BioMEMS Microfluid Lab, Tehran, Iran
[5] ACECR, Royan Inst Stem Cell Biol & Technol, Dept Canc Med, Cell Sci Res Ctr, Isar 11, Babol Sar 4713818983, Iran
[6] Univ Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Tehran, Iran
[7] Southern Univ Sci & Technol, SUStech UTS Joint Res Ctr Biomed Mat & Devices, Shenzhen 518055, Peoples R China
[8] Sechenov Univ, Inst Mol Med, Moscow 119991, Russia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
Planar mixing units; Optimization; Numerical simulation; Chaotic advection; Mixing index; Pressure drop; GRAPHENE-PLATINUM NANOPARTICLES; MICROFLUIDIC SYNTHESIS; CHAOTIC ADVECTION; NANOFLUID; FLOW; FABRICATION; MINICHANNEL; TECHNOLOGY; SPLIT; CELL;
D O I
10.1007/s10404-020-02367-x
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Planar micromixers with repetitive units have received substantial research interest since they allow low cost, lab-on-a-chip (LOC), and point-of-care (POC) systems to achieve a proper level of mixing for any given process. This paper presents an efficient planar micromixer that combines four types of mixing units, including convergent-divergent, circular, rhombic, and G-shaped micromixers. Their combinations and resulting effects on the mixing efficiency are numerically and experimentally investigated. A comprehensive Taguchi design of experiment method was used to reduce the number of the combinations from 1024 to only 16, among which a micromixer made of rhombic and G-shaped units readily showed a mixing efficiency beyond 80% over a wide range of inlet Reynolds numbers 0.001-0.3 and 35-65; meanwhile, a pressure drop as low as 12 kPa was reported. The velocity and concentration fields and their gradients within the nominated micromixer were analyzed, providing a better understanding of the mixing mechanism. These results offer design insights for further development of planar micromixers with repetitive unites for low-cost LOC and POC devices.
引用
收藏
页数:15
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