The use of scaffolds in the management of art articular cartilage injury

被引:44
作者
Safran, Marc R. [1 ]
Kim, Hubert [1 ]
Zaffagnini, Stefano [2 ]
机构
[1] Univ Calif San Francisco, Dept Orthopaed Surg, San Francisco, CA 94143 USA
[2] Rizzoli Orthopaed Inst, Biomech Lab, Bologna, Italy
关键词
D O I
10.5435/00124635-200806000-00002
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Managing articular cartilage injury continues to be a difficult challenge for the clinician. Although the short- and intermediateterm results of autologous chondrocyte implantation appear to be favorable, resources are being directed toward research to improve the technology. One promising area of investigation is the combination of cultured chondrocytes with scaffolds. Clinicians desire techniques that may be implanted easily, reduce surgical morbidity, do not require harvesting of other tissues, exhibit enhanced cell proliferation and maturation, have easier phenotype maintenance, and allow for efficient and complete integration with surrounding articular cartilage. The characteristics that make scaffolds optimal for clinical use are that they be biocompatible, biodegradable, permeable, reproducible, mechanically stable, noncytotoxic, and capable of serving as a temporary support for the cells while allowing for eventual replacement by matrix components synthesized by the implanted cells. Clinical experience is growing with three scaffold-based cartilage repair techniques, each using a different type of scaffold material: matrix-induced autologous chondrocyte implantation, a hyaluronic acid-based scaffold, and a composite polylactic/polyglycolic acid polymer fleece. Clinical results are encouraging. Future directions in scaffold-based cartilage repair include bioactive and spatially oriented scaffolds.
引用
收藏
页码:306 / 311
页数:6
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