Mechanical and tribological properties of poly(hydroxyethyl methacrylate) hydrogels as articular cartilage substitutes

被引：31

作者：

Bostan, L. ^{[1
,2
]}

Trunfio-Sfarghiu, A. -M. ^{[1
]}

Verestiuc, L. ^{[3
]}

Popa, M. I. ^{[2
]}

Munteanu, F. ^{[3
]}

Rieu, J. -P. ^{[4
]}

Berthier, Y. ^{[1
]}

机构：

[1] Univ Lyon, Contact & Struct Mech Lab, CNRS INSA Lyon, UMR5259, F-69621 Villeurbanne, France

[2] Gheorghe Asachi Tech Univ Iasi, Fac Chem Engn & Environm Protect, Iasi, Romania

[3] Gr T Popa Univ Med & Pharm, Fac Med Bioengn, Iasi, Romania

[4] Univ Lyon 1, CNRS, Lab Nanostruct & Phys Condensed Mat, UMR5586, F-69622 Villeurbanne, France

来源：

TRIBOLOGY INTERNATIONAL | 2012年 / 46卷 / 01期

关键词：

Hydrogel; p(HEMA); Articular cartilage; Mechanical properties; FRICTION; SYSTEM; FLUID;

D O I：

10.1016/j.triboint.2011.06.035

中图分类号：

TH [机械、仪表工业];

学科分类号：

0802 ;

摘要：

Poly(hydroxyethyl methacrylate) (p(HEMA)) hydrogels have been proposed as promising biomaterials to replace damaged articular cartilage. A major obstacle to their use as replacement bearing tissue is their poor mechanical properties in comparison with healthy articular cartilage. The purpose of this study was to obtain p(HEMA) hydrogels with physicochemical and mechanical properties close to healthy articular cartilage, by introducing a hydrophilic monomer, namely acrylic acid (AA). Formulations of hydrogels with different amounts of hydrophilic monomer (acrylic acid, AA) were synthesized and tested: p(HEMA), p(HEMA-co-5%AA), p(HEMA-co-25%AA). The macro-mechanical tests were reproduced at nanoscale in order to verify if the superficial properties of the hydrogels are similar to the bulk ones. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

引用

页码：215 / 224

页数：10

共 25 条

[1] The role of interstitial fluid pressurization and surface porosities on the boundary friction of articular cartilage [J].