Application of Cyclohexane-1,3-diones in the Synthesis of Six-Membered Nitrogen-Containing Heterocycles

Cyclohexane-1,3-dione and its derivatives are imperative precursors in synthetic organic chemistry as they are useful intermediates for the synthesis of a wide range of biologically active natural products, heterocycles and pharmaceuticals. Recently, cyclohexane-1,3-diones have been used for the synthesis of varied array of six-membered nitrogen-containing heterocycles in the presence of aldehydes, acetoacetic esters, malononitrile, chalcones, coumarins, acetophenones, amino acids, amines, etc. under catalytic and non-catalytic conditions. Newest studies on the importance of these heterocycles motivated us to compile all the recently developed processes which include the fabrication of six-membered nitrogen heterocycles. This article is mainly focused on the efficient synthesis of six-membered N-heterocycles i. e. 1,4-dihydropyridine, acridine-1,8-diones, benzoacridinones, quinolones and pyridine derivatives from cyclohexane-1,3-diones as one of the substrates, published for the last ten years.