Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea

被引：87

作者：

Lee, JY

Kim, HY

Kim, KH

Kim, SM

Jang, MK

Park, JY

Lee, JH

Kim, JH

Yoo, JY

机构：

[1] Hallym Univ, Med Ctr, Kangdong Sacred Heart Hosp, Dept Internal Med,Div Gastroenterol, Seoul 134701, South Korea

[2] Hallym Univ, Med Ctr, Lab Gastroenterol & Hepatol, Seoul, South Korea

[3] Univ Ulsan, Coll Med, Dept Internal Med, Seoul, South Korea

来源：

CANCER LETTERS | 2005年 / 225卷 / 02期

关键词：

gastric cancer; peptic ulcer; interleukin-10; tumor necrosis factor-alpha; polymorphism; Helicobacter pylori;

D O I：

10.1016/j.canlet.2004.11.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We performed this study to determine the role of polymorphisms of the IL-10 and TNF-alpha promoter genes in the carcinogenesis/pathogenesis of gastric cancer (GC) and peptic ulcer diseases (PUD) in Korea. A total of 232 patients with gastric diseases and 120 healthy controls were included. Polymorphisms of IL-10-1082/-592 gene and TNF-A-308 gene were genotyped by PCR-RFLP. There were no differences in genotypes and allele frequencies of IL-10 and TNF-A polymorphism between study group with GC or PUD and control group. In addition, there were no differences in genotypic frequencies according to H. pylori infection status, location of GC, and histologic type of GC. In conclusion, IL-10-1082/-592 and TNF-A308 genetic polymorphisms may not be the important contributors to GC in Korea. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：207 / 214

页数：8

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