Should we continue to use renin-angiotensin-aldosterone system blockers in patients with COVID-19?

被引：1

作者：

Copur, Sidar ^{[1
]}

Kanbay, Asiye ^{[2
]}

Kanbay, Mehmet ^{[3
]}

机构：

[1] Koc Univ, Sch Med, Dept Med, Istanbul, Turkey

[2] Istanbul Medicana Atasehir Hosp, Dept Pulm Med, Istanbul, Turkey

[3] Koc Univ, Sch Med, Div Nephrol, Dept Med, Istanbul, Turkey

来源：

CLINICAL KIDNEY JOURNAL | 2022年 / 15卷 / 05期

关键词：

chronic kidney disease; COVID-19; hypertension; renin angiotensin system;

D O I：

10.1093/ckj/sfac001

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with chronic kidney disease, chronic heart failure and hypertension have an increased risk of coronavirus disease 2019 (COVID-19)-related death. Renin-angiotensin-aldosterone system (RAS) blockers are commonly prescribed to decrease morbidity and mortality in these conditions. Following the pre-clinical demonstration of COVID-19 viral entry into cells via angiotensin-converting enzyme-2, the use of RAS blockers was questioned in infected individuals. Theodorakopoulou et al. extensively review the pathophysiology behind that hypothesis and observational or clinical trials on RAS blockers and COVID-19. Despite being a scientific hot spot of an ongoing debate, discontinuation of RAS blockers is not associated with improved clinical outcomes in COVID-19 and may have potential harmful effects, including exacerbation of the underlying disease.

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收藏

页码：852 / 854

页数：3

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