Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates

被引：146

作者：

Joshi-Pangu, Amruta ^{[1
]}

Wang, Chao-Yuan ^{[1
]}

Biscoe, Mark R. ^{[1
]}

机构：

[1] CUNY City Coll, Dept Chem, New York, NY 10031 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 22期

基金：

美国国家科学基金会;

关键词：

N-HETEROCYCLIC CARBENES; GRIGNARD-REAGENTS; ALKYL-HALIDES; LIGAND; REACTIVITY; COMPLEXES; BROMIDES;

D O I：

10.1021/ja202769t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a Ni-catalyzed process for the cross-coupling of tertiary alkyl nudeophiles and aryl bromides. This process is extremely general for a wide range of electrophiles and generally occurs with a ratio of retention to isomerization >30:1. The same procedure also accommodates the use of aryl triflates, vinyl chlorides, and vinyl bromides as the electrophilic component.

引用

页码：8478 / 8481

页数：4

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