Ionic Dioxidovanadium(V) Complexes with Schiff-Base Ligands as Potential Insulin-Mimetic Agents-Substituent Effect on Structure and Stability

被引：3

作者：

Jurowska, Anna ^{[1
]}

Szklarzewicz, Janusz ^{[1
]}

Hodorowicz, Maciej ^{[1
]}

Serafin, Wiktoria ^{[1
]}

Zangrando, Ennio ^{[2
]}

Mahmoudi, Ghodrat ^{[3
]}

机构：

[1] Jagiellonian Univ, Fac Chem, Gronostajowa 2, PL-30387 Krakow, Poland

[2] Univ Trieste, Dept Chem & Pharmaceut Sci, Via L Giorgieri 1, I-34127 Trieste, Italy

[3] Univ Maragheh, Fac Sci, Dept Chem, POB 55181-83111, Maragheh, Iran

来源：

MOLECULES | 2022年 / 27卷 / 20期

关键词：

vanadium; ionic complexes; Schiff base ligand; crystal structure; UV-Vis spectra; VANADIUM COMPOUNDS; DIOXIDO-VANADIUM(V) COMPLEXES; CRYSTAL-STRUCTURE; COPPER(II); CHEMISTRY; BMOV;

D O I：

10.3390/molecules27206942

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four dioxidovanadium(V) complexes with Schiff-base ligands based on 2-hydroxybenzhydrazide with four different substituted salicylaldehydes (5-chlorosalicylaldehyde, 3,5-dichlorosalicylaldehyde, 5-nitrosalicylaldehyde, 3-bromo-5-chlorosalicylaldehyde) were synthesized and described, by using V2O5 and triethylamine. The single crystal X-ray structure measurements as well as elemental analyses and IR spectra confirmed the formulas of the ionic complexes with a protonated triethylamine acting as counterion, HTEA[VO2(L)] (HL = Schiff-base ligand). The kinetic stability of the complexes at pH = 2 and 7 was discussed with respect to the neutral vanadium(V) complexes previously studied as potential insulin-mimetic agents. A correlation between the substituents in an aromatic ring of the Schiff-base ligands with crystal packing, and also with the stability of the compounds, was presented.

引用

页数：12

共 5 条

[1] Protonated amino alcohols as cations in synthesis of vanadium(V) complexes with Schiff base ligands as potential insulin-mimetic agents
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JOURNAL OF MOLECULAR STRUCTURE, 2024, 1305
[2] V(III) and V(IV) Schiff base complexes as potential insulin-mimetic compounds - Comparison, characterization and biological activity
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POLYHEDRON, 2022, 215
[3] Alkali metals and ammonium as cations in dioxidovanadium(V) complexes with Schiff base ligands - structure, solubility and stability in biological media
Jurowska, Anna
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JOURNAL OF MOLECULAR STRUCTURE, 2024, 1317
[4] Investigation of derivatized schiff base ligands of 1,2,4-triazole amine and their oxovanadium(IV) complexes: Synthesis, structure, DNA binding, alkaline phosphatase inhibition, biological screening, and insulin mimetic properties
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Ali, S.
Tahir, M. N.
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Abbas, Q.
Qureshi, I. Z.
Shahzadi, S.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2015, 85 (09) : 2183 - 2197
[5] Design, synthesis and characterization of novel binary V(V)-Schiff base materials linked with insulin-mimetic vanadium-induced differentiation, of 3T3-L1 fibroblasts to adipocytes. Structure-function correlations at the molecular level
Halevas, E.
Tsave, O.
Yavropoulou, M. P.
Hatzidimitriou, A.
Yovos, J. G.
Psycharis, V.
Gabriel, C.
Salifoglou, A.
JOURNAL OF INORGANIC BIOCHEMISTRY, 2015, 147 : 99 - 115

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