Antiproliferative Activity of Combined Biochanin A and Ginsenoside Rh2 on MDA-MB-231 and MCF-7 Human Breast Cancer Cells

被引：39

作者：

Ren, Guixing ^{[1
]}

Shi, Zhenxing ^{[2
]}

Teng, Cong ^{[3
]}

Yao, Yang ^{[3
]}

机构：

[1] Chengdu Univ, Coll Pharm & Biol Engn, 1 Shilling Rd,Chenglo Ave, Chengdu 610106, Sichuan, Peoples R China

[2] Univ Liege, Lab Biomass & Green Technol, Gembloux Agrobio Tech, Passage Deportes 2, B-5030 Gembloux, Belgium

[3] Chinese Acad Agr Sci, Inst Crop Sci, 80 South Xueyuan Rd, Beijing 100081, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 11期

关键词：

synergy; biochanin A; Rh-2; breast cancer; antiproliferative activity; PROLIFERATION; APOPTOSIS; GROWTH; RH2; INHIBITION; ACTIVATION; MECHANISM; INVASION; SYNERGY; PROTEIN;

D O I：

10.3390/molecules23112908

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is the most frequently diagnosed cancer in women worldwide. The antiproliferative activities of biochanin A (BA) and ginsenoside Rh-2 were determined by evaluating their inhibitory effect on MDA-MB-231 human breast cancer cell proliferation. The combination of BA with Rh-2 was also assessed. In MDA cells, combination treatment led to a decrease in the EC50 values of BA and Rh-2 to 25.20 mu M and 22.75 mu M, respectively. In MCF-7 cells, the EC50 values of combined BA and Rh-2 decreased to 27.68 mu M and 25.41 mu M, respectively. BA combined with Rh-2 also improved the inhibition of MDA-MB-231 and MCF-7 cell migration and invasion compared to the individual compounds. Western blot analysis demonstrated upregulation in p-p53, p-p38, and p-ASK1 proteins while levels of TRAF2 were downregulated. These results suggest that BA combined with Rh-2 exhibits synergistic effects against MDA-MB-231 and MCF-7 cell proliferation.

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页数：14

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