Time to target the circadian clock for drug discovery

被引：38

作者：

Rasmussen, Emil Sjulstok ^{[1
]}

Takahashi, Joseph S. ^{[1
,2
]}

Green, Carla B. ^{[1
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA

[2] Univ Texas Southwestern Med Dallas, Howard Hughes Med Inst, Dallas, TX USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2022年 / 47卷 / 09期

关键词：

REV-ERB-ALPHA; ARYL-HYDROCARBON RECEPTOR; CRYSTAL-STRUCTURE; TRANSCRIPTIONAL ARCHITECTURE; CRYPTOCHROME; IDENTIFICATION; PROTEINS; RHYTHMS; HEME; CRY1;

D O I：

10.1016/j.tibs.2022.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse and extensive processes throughout the body. The clock mechanism comprises a core transcription/translation negative feedback loop that is modulated by a complex set of additional interlocking feedback loops. Pharmacological manipulation of the clock may be valuable for treating many maladies including jet lag, shift work and related sleep disorders, various meta-bolic diseases, and cancer. We review recent identification of small-molecule clock modulators and discuss the biochemical features of the core clock that may be amenable to future drug discovery.

引用

页码：745 / 758

页数：14

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