Bougainvinones A-H, Peltogynoids from the Stem Bark of Purple Bougainvillea spectabilis and Their Cytotoxic Activity

被引：17

作者：

Do, Lien T. M. ^{[1
,2
]}

Aree, Thammarat ^{[1
]}

Siripong, Pongpun ^{[4
]}

Pham, Tuyen N. K. ^{[2
]}

Nguyen, Phung K. P. ^{[3
]}

Tip-pyang, Santi ^{[1
]}

机构：

[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Nat Prod Res Unit, Bangkok 10330, Thailand

[2] Sai Gon Univ, Ho Chi Minh City 748355, Vietnam

[3] Natl Univ Ho Chi Minh City, Univ Sci, Ho Chi Minh City 748355, Vietnam

[4] Natl Canc Inst, Div Res, Nat Prod Res Sect, Bangkok 10400, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 04期

关键词：

FLAVONOIDS; LEAVES; EXTRACT;

D O I：

10.1021/acs.jnatprod.5b00996

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new peltogynoids, named bougainvinones A-H (1-8), were obtained from the stem bark of Bougainvillea spectabilis. Their structures were elucidated by means of physical data (1D and 2D NMR, HRESIMS) and single-crystal X-ray crystallographic analyses. The peltogynoids, a rare type of modified flavonoids, are reported for the first time from this species of the genus Bougainvillea. All isolated compounds were evaluated for their cytotoxic effects against five cancer cell lines including KB, Hela S-3, HT-29, MCF-7, and HepG2. Among them, compound 7 showed cytotoxicity against five cancer cell lines with IC50 values in the 7.4-9.7 mu M range, and compounds 2 and 3 exhibited cytotoxicity against the KB cell line with IC50 values of 6.6 and 9.0 mu M.

引用

页码：939 / 945

页数：7

共 27 条

[1] Two New Peltogynoids from Acacia nilotica Delile with Kinase Inhibitory Activity [J].